HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bui, K. C. Articles by Bartlett, R. H. Search for Related Content PubMed PubMed Citation Articles by Bui, K. C. Articles by Bartlett, R. H.

The Journal of Thoracic and Cardiovascular Surgery, Vol 101, 973-983, Copyright © 1991 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Plasma prostanoids in neonates with pulmonary hypertension treated with conventional therapy and with extracorporeal membrane oxygenation

KC Bui, C Hammerman, RB Hirschl, V Hill, SM Snedecor, R Schumacher and RH Bartlett
Department of Pediatrics, Wyler Children's Hospital, University of Chicago, Pritzker School of Medicine, Ill.

Thromboxane may be a mediator of pulmonary hypertension in the neonate. Acute thromboxane-mediated pulmonary hypertension has been described in sheep receiving extracorporeal membrane oxygenation, which raises concerns about a potential thromboxane-mediated exacerbation of pulmonary hypertension in human neonates with severe pulmonary hypertension who are treated with extracorporeal membrane oxygenation. We measured plasma levels of thromboxane, prostaglandin F2 alpha, and 6- keto-prostaglandin F1 alpha in infants with pulmonary hypertension, some of whom were treated medically and some of whom were treated with extracorporeal membrane oxygenation. Plasma levels of all three prostanoids were elevated in infants with pulmonary hypertension and decreased with time, whether the neonates were treated with extracorporeal membrane oxygenation or with medical management alone. In infants treated with extracorporeal membrane oxygenation, we collected samples simultaneously from preoxygenator sites, postoxygenator sites, and umbilical artery catheter. We could demonstrate no significant difference in plasma prostanoid levels across the oxygenator. In two patients, plasma thromboxane and prostaglandin F2 alpha levels measured shortly after a platelet transfusion were distinctly higher in the umbilical artery catheter than in venous samples.

This article has been cited by other articles:

				I. M. Cheifetz, M. L. Cannon, D. M. Craig, G. Quick, F. H. Kern, P. K. Smith, R. M. Ungerleider, and J. N. Meliones Liquid Ventilation Improves Pulmonary Function And Cardiac Output In A Neonatal Swine Model Of Cardiopulmonary Bypass J. Thorac. Cardiovasc. Surg., March 1, 1998; 115(3): 528 - 535. [Abstract] [Full Text]

				F. Brus, W. van Oeveren, A. Okken, and S. B. Oetomo Number and Activation of Circulating Polymorphonuclear Leukocytes and Platelets Are Associated with Neonatal Respiratory Distress Syndrome Severity Pediatrics, May 1, 1997; 99(5): 672 - 680. [Abstract] [Full Text] [PDF]