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The Journal of Thoracic and Cardiovascular Surgery, Vol 102, 62-73, Copyright © 1991 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
JI Fann, DD Glower, DC Miller, KL Yun, JS Rankin, WD White, RL Smith, WG Wolfe and NE Shumway
Two hundred fifty-two patients underwent operation for type A aortic
dissection at Stanford University Medical Center from 1963 to 1987 and Duke
University Medical Center from 1975 to 1988. Sixty-seven percent had an
acute type A dissection and 33% had a chronic type A dissection. In
addition to repair or replacement of the ascending aorta, 121 patients
(48%) required an aortic valve procedure. Valve resuspension was performed
in 46 (39 acute type A and 7 chronic type A), with an operative mortality
rate of 13% +/- 5% (+/- 70% confidence limits), and aortic valve
replacement in 75 (36 acute type A and 39 chronic type A), with an
operative mortality rate of 20% +/- 5% (p = not significant versus
resuspension). The operative mortality rate for patients requiring only
repair or replacement of the ascending aorta was 32% +/- 4%. Indications
for valve replacement included coexistent (nonacute) aortic valve disease,
Marfan's syndrome, annuloaortic ectasia, and cases in which successful
resuspension could not be accomplished. The overall actuarial survival rate
for all patients was 59% +/- 3% (+/- 1 standard error of the mean), 40% +/-
4%, and 25% +/- 5% at 5, 10, and 15 years, respectively. Survival rates at
these same times for patients with valve resuspension were 67% +/- 8%, 52%
+/- 10%, and 26% +/- 19%, respectively; for patients who required aortic
valve replacement, these survival rates were 70% +/- 5%, 39% +/- 8%, and
21% +/- 11%; finally, patients who received only an ascending aortic
procedure had survival probabilities of 51% +/- 5%, 37% +/- 6%, and 23% +/-
6% (p = not significant versus resuspension versus aortic valve
replacement). Multivariate analysis showed advanced age (p less than
0.001), previous cardiac or aortic operation (p less than 0.001), more
preoperative dissection complications (p = 0.002), and earlier operative
date (p = 0.038) to be the only significant, independent factors that
increased the likelihood of early or late death. The type of aortic valve
procedure (resuspension versus aortic valve replacement versus none) was
not a significant predictor of mortality. Two of 46 patients with valve
resuspension required late aortic valve replacement (freedom from aortic
valve replacement: 100% and 80% +/- 13% at 5 and 10 years, respectively),
as did 4 of 75 patients with initial aortic valve replacement (freedom from
repeat aortic valve replacement: 98% +/- 2% and 73% +/- 13%,
respectively).(ABSTRACT TRUNCATED AT 400 WORDS)
ARTICLES
Preservation of aortic valve in type A aortic dissection complicated by aortic regurgitation
Department of Cardiovascular Surgery, Stanford University School of Medicine, CA 94305-5247.
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