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The Journal of Thoracic and Cardiovascular Surgery, Vol 102, 333-339, Copyright © 1991 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
LR Kaiser, JD Cooper, EP Trulock, MK Pasque, A Triantafillou and D Haydock
Classic transplantation dogma mandated bilateral lung replacement for lung
transplant candidates with end-stage emphysema to avoid air trapping in the
native lung and subsequent crowding of the newly transplanted lung. During
a recent 12-month period 11 patients with emphysema received a single lung
transplant. There was no hospital mortality and only one patient had any
notable degree of air trapping in the native lung. Substantial improvement
in pulmonary function was seen as early as 2 weeks after transplantation,
with significant functional improvement seen by 6 weeks, despite some
residual ventilation-perfusion mismatch. We have demonstrated the utility
and safety of single lung transplantation for patients with end-stage
emphysema, and it is our operation of choice in recipients more than 50
years of age.
ARTICLES
The evolution of single lung transplantation for emphysema. The Washington University Lung Transplant Group
Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, Mo.
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