HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ichinose, Y. Articles by Ohta, M. Search for Related Content PubMed PubMed Citation Articles by Ichinose, Y. Articles by Ohta, M.

The Journal of Thoracic and Cardiovascular Surgery, Vol 102, 418-424, Copyright © 1991 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Synchronous lung cancers defined by deoxyribonucleic acid flow cytometry

Y Ichinose, N Hara and M Ohta
Department of Chest Surgery, National Kyushu Cancer Center, Fukuoka, Japan.

When two pulmonary tumors are seen simultaneously in patients with lung cancer, it always raises a question as to whether the lesions are synchronous lung cancers or lung cancer with intrapulmonary metastasis. To settle this issue, we used deoxyribonucleic acid flow cytometry. Deoxyribonucleic acid ploidy patterns of tumors were able to be analyzed in 14 patients with two simultaneous pulmonary tumors resected by operation. These two tumors, with completely different patterns of deoxyribonucleic acid ploidy, were defined as synchronous lung cancers. Tumors were defined as lung cancer with intrapulmonary metastasis when both tumors showed diploidy or when at least one deoxyribonucleic acid index of abnormal clones between two aneuploid tumors was the same or almost identical. Tumors of the five patients with stage I disease were classified as synchronous lung cancers according to the criteria involving deoxyribonucleic acid flow cytometry. Both tumors were adenocarcinomas in four patients and large-cell and squamous cell carcinomas in one. Both tumors in four patients were located in the same lobe but different segments. All but one patient with different histologic types are alive without recurrence from 24 to 100 months after operation. Tumors of the nine patients with stage III disease in whom intrapulmonary metastasis was clinically suspected were classified as lung cancer with intrapulmonary metastasis according to the criteria. These data suggest that deoxyribonucleic acid flow cytometry of tumors may have diagnostic value in determining synchronous lung cancers.

This article has been cited by other articles:

				A. Oliaro, P. L. Filosso, A. Cavallo, R. Giobbe, C. Mossetti, P. Lyberis, R. C. Cristofori, and E. Ruffini The significance of intrapulmonary metastasis in non-small cell lung cancer: upstaging or downstaging? A re-appraisal for the next TNM staging system. Eur. J. Cardiothorac. Surg., August 1, 2008; 34(2): 438 - 443. [Abstract] [Full Text] [PDF]

				Y.-W. Tung, C.-P. Hsu, S.-E. Shai, J.-Y. Hsia, S.-S. Yang, and C.-Y. Chen Surgical feasibility of ipsilateral multifocal non-small cell lung cancer in different lobes: excellent survival in node-negative subgroup Eur. J. Cardiothorac. Surg., December 1, 2003; 24(6): 1008 - 1012. [Abstract] [Full Text] [PDF]

				T. Okumura, H. Asamura, K. Suzuki, H. Kondo, and R. Tsuchiya Intrapulmonary metastasis of non-small cell lung cancer: A prognostic assessment J. Thorac. Cardiovasc. Surg., July 1, 2001; 122(1): 24 - 28. [Abstract] [Full Text] [PDF]

				J. Nakajima, A. Furuse, T. Oka, T. Kohno, and T. Ohtsuka Excellent Survival in a Subgroup of Patients With Intrapulmonary Metastasis of Lung Cancer Ann. Thorac. Surg., January 1, 1996; 61(1): 158 - 162. [Abstract] [Full Text]

				T. Antakli, R. F. Schaefer, J. E. Rutherford, and R. C. Read Second Primary Lung Cancer Ann. Thorac. Surg., April 1, 1995; 59(4): 863 - 867. [Abstract] [Full Text]