| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Thoracic and Cardiovascular Surgery, Vol 102, 515-525, Copyright © 1991 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
NJ Jansen, W van Oeveren, L van den Broek, HM Oudemans-van Straaten, CP Stoutenbeek, MC Joen, KJ Roozendaal, L Eysman and CR Wildevuur
A placebo-controlled double-blind study of patients undergoing
cardiopulmonary bypass was conducted, comparing the effects of
dexamethasone and a placebo on the activation of the plasmatic systems and
blood cells and on the postoperative course after cardiopulmonary bypass.
In the placebo group two patterns of blood activation could be
distinguished. From the start of bypass, blood-material interaction caused
an increase in complement C3a and elastase concentration. After release of
the aortic cross-clamp, a statistically significant increase was observed
in tumor necrosis factor, leukotriene B4, and tissue plasminogen activator
activity (p less than 0.01, p less than 0.05, p less than 0.05,
respectively). Dexamethasone treatment was not able to inhibit complement
activation and elastase release during cardiopulmonary bypass. However,
dexamethasone treatment effectively inhibited the increase in tumor
necrosis factor, leukotriene B4, and tissue plasminogen activator activity
after release of the crossclamp (p less than 0.01 compared with the placebo
group). In the postoperative period the patients in the placebo group had
hyperthermia and hypotension and required considerable intravenous fluid
administration and cardiotonic treatment. The dexamethasone-treated
patients, however, showed normothermia (p less than 0.01), had
significantly higher blood pressures (p less than 0.01) without supportive
treatment, and consequently were in the intensive care unit for a shorter
period of time. We conclude that dexamethasone prevents the hemodynamic
instability after cardiopulmonary bypass and thus improves the
postoperative course by inhibition of the leukocyte and tissue plasminogen
activator activity generated after release of the aortic crossclamp.
ARTICLES
Inhibition by dexamethasone of the reperfusion phenomena in cardiopulmonary bypass
Department of Cardio-Pulmonary Surgery, University Hospital, Groningen, The Netherlands.
This article has been cited by other articles:
|
|
 |
|
  R. P. Whitlock, S. Chan, P.J. Devereaux, J. Sun, F. D. Rubens, K. Thorlund, and K. H.T. Teoh Clinical benefit of steroid use in patients undergoing cardiopulmonary bypass: a meta-analysis of randomized trials Eur. Heart J., November 1, 2008; 29(21): 2592 - 2600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A Hassantash, G. R Omrani, N. Givtaj, and M. Afrakhteh Pharmacological Prevention of the Deleterious Effects of Cardiopulmonary Bypass Asian Cardiovasc Thorac Ann, June 1, 2007; 15(3): 218 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sano, S. Morita, M. Masuda, and H. Yasui Minor Infection Encouraged by Steroid Administration During Cardiac Surgery Asian Cardiovasc Thorac Ann, December 1, 2006; 14(6): 505 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. J. Liakopoulos, N. Teucher, C. Muhlfeld, P. Middel, G. Heusch, F. A. Schoendube, and H. Dorge Prevention of TNFalpha-associated myocardial dysfunction resulting from cardiopulmonary bypass and cardioplegic arrest by glucocorticoid treatment. Eur. J. Cardiothorac. Surg., August 1, 2006; 30(2): 263 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-H. Hsing, M.-Y. Hsieh, W.-Y. Chen, E. Cheung So, B.-C. Cheng, and M.-S. Chang Induction of Interleukin-19 and Interleukin-22 After Cardiac Surgery With Cardiopulmonary Bypass Ann. Thorac. Surg., June 1, 2006; 81(6): 2196 - 2201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Kozik and J. S. Tweddell Characterizing the Inflammatory Response to Cardiopulmonary Bypass in Children Ann. Thorac. Surg., June 1, 2006; 81(6): S2347 - S2354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Gao, R. Taha, D. Gauvin, L. B. Othmen, Y. Wang, and G. Blaise Postoperative Cognitive Dysfunction After Cardiac Surgery Chest, November 1, 2005; 128(5): 3664 - 3670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Morariu, B. G. Loef, L. P. H. J. Aarts, G. W. Rietman, G. Rakhorst, W. van Oeveren, and A. H. Epema Dexamethasone: Benefit and Prejudice for Patients Undergoing On-Pump Coronary Artery Bypass Grafting: A Study on Myocardial, Pulmonary, Renal, Intestinal, and Hepatic Injury Chest, October 1, 2005; 128(4): 2677 - 2687. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Prasongsukarn, J. G. Abel, W.R. E. Jamieson, A. Cheung, J. A. Russell, K. R. Walley, and S. V. Lichtenstein The effects of steroids on the occurrence of postoperative atrial fibrillation after coronary artery bypass grafting surgery: A prospective randomized trial J. Thorac. Cardiovasc. Surg., July 1, 2005; 130(1): 93 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. D. Rubens, H. Nathan, R. Labow, K. S. Williams, D. Wozny, J. Karsh, M. Ruel, and T. Mesana Effects of Methylprednisolone and a Biocompatible Copolymer Circuit on Blood Activation During Cardiopulmonary Bypass Ann. Thorac. Surg., February 1, 2005; 79(2): 655 - 665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. G. Loef, R. H. Henning, A. H. Epema, G. W. Rietman, W. van Oeveren, G. J. Navis, and T. Ebels Effect of dexamethasone on perioperative renal function impairment during cardiac surgery with cardiopulmonary bypass Br. J. Anaesth., December 1, 2004; 93(6): 793 - 798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bourbon, M. Vionnet, P. Leprince, E. Vaissier, J. Copeland, P. McDonagh, P. Debre, and I. Gandjbakhch The effect of methylprednisolone treatment on the cardiopulmonary bypass-induced systemic inflammatory response Eur. J. Cardiothorac. Surg., November 1, 2004; 26(5): 932 - 938. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R de Vroege, F te Meerman, L Eijsman, W R Wildevuur, C. R. Wildevuur, and W van Oeveren Induction and detection of disturbed homeostasis in cardiopulmonary bypass Perfusion, September 1, 2004; 19(5): 267 - 276. [Abstract] [PDF]
|
|
|
|
 |
|
 R. de Vroege, W. van Oeveren, J. van Klarenbosch, W. Stooker, M. A. J. M. Huybregts, C. E. Hack, L. van Barneveld, L. Eijsman, and C. R. H. Wildevuur The Impact of Heparin-Coated Cardiopulmonary Bypass Circuits on Pulmonary Function and the Release of Inflammatory Mediators Anesth. Analg., June 1, 2004; 98(6): 1586 - 1594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Celik, N. Gormus, S. Okesli, Z. I. Gormus, and H. Solak Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass: effects on TNF-{alpha}, IL-6, IL-8, IL-10 Perfusion, May 1, 2004; 19(3): 185 - 191. [Abstract] [PDF]
|
|
|
|
|
|
M. Farstad, J. K. Heltne, S. E. Rynning, H. Onarheim, A. Mongstad, F. Eliassen, and P. Husby Can the use of methylprednisolone, vitamin C, or {alpha}-trinositol prevent cold-induced fluid extravasation during cardiopulmonary bypass in piglets? J. Thorac. Cardiovasc. Surg., February 1, 2004; 127(2): 525 - 534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F D Rubens and T Mesana The inflammatory response to cardiopulmonary bypass: a therapeutic overview Perfusion, January 1, 2004; 19(1_suppl): S5 - S12. [Abstract] [PDF]
|
|
|
|
|
|
L. Lindberg, C. Forsell, P. Jogi, and A.-K. Olsson Effects of dexamethasone on clinical course, C-reactive protein, S100B protein and von Willebrand factor antigen after paediatric cardiac surgery Br. J. Anaesth., June 1, 2003; 90(6): 728 - 732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M de Baar, J C Diephuis, K G M Moons, J Holtkamp, R Hijman, and C J Kalkman The effect of zero-balanced ultrafiltration during cardiopulmonary bypass on S100b release and cognitive function Perfusion, January 1, 2003; 18(1): 9 - 14. [Abstract] [PDF]
|
|
|
|
|
|
Y. Sason-Ton, R. Ben Abraham, D. Lotan, O. Dagan, T. Prince, Z. Barzilay, and G. Paret Tumor necrosis factor and clinical and metabolic courses after cardiac surgery in children J. Thorac. Cardiovasc. Surg., November 1, 2002; 124(5): 991 - 998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. El Azab, P. M. J. Rosseel, J. J. de Lange, A. B. J Groeneveld, R. van Strik, E. M. van Wijk, and G. J. Scheffer Dexamethasone decreases the pro- to anti-inflammatory cytokine ratio during cardiac surgery Br. J. Anaesth., April 1, 2002; 88(4): 496 - 501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P Vallely, P. G Bannon, C. F Hughes, and L. Kritharides Endothelial Cell Adhesion Molecules and Cardiopulmonary Bypass Asian Cardiovasc Thorac Ann, December 1, 2001; 9(4): 349 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. P. Schurr, G. Zund, S. P. Hoerstrup, J. Grunenfelder, F. E. Maly, P. R. Vogt, and M. I. Turina Preoperative administration of steroids: influence on adhesion molecules and cytokines after cardiopulmonary bypass Ann. Thorac. Surg., October 1, 2001; 72(4): 1316 - 1320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Bokesch, M. B. Kapural, E. B. Mossad, M. Cavaglia, E. Appachi, J. J. Drummond-Webb, and R. B.B. Mee Do peritoneal catheters remove pro-inflammatory cytokines after cardiopulmonary bypass in neonates? Ann. Thorac. Surg., August 1, 2000; 70(2): 639 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-P. Yared, N. J. Starr, F. K. Torres, C. A. Bashour, G. Bourdakos, M. Piedmonte, J. A. Michener, J. A. Davis, and T. E. Rosenberger Effects of single dose, postinduction dexamethasone on recovery after cardiac surgery Ann. Thorac. Surg., May 1, 2000; 69(5): 1420 - 1424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Bronicki, C. L. Backer, H. P. Baden, C. Mavroudis, S. E. Crawford, and T. P. Green Dexamethasone reduces the inflammatory response to cardiopulmonary bypass in children Ann. Thorac. Surg., May 1, 2000; 69(5): 1490 - 1495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ozawa, K. Yoshihara, N. Koyama, Y. Watanabe, N. Shiono, and Y. Takanashi Clinical efficacy of heparin-bonded bypass circuits related to cytokine responses in children Ann. Thorac. Surg., February 1, 2000; 69(2): 584 - 590. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Eagle, R. A. Guyton, R. Davidoff, G. A. Ewy, J. Fonger, T. J. Gardner, J. P. Gott, H. C. Herrmann, R. A. Marlow, W. C. Nugent, et al. ACC/AHA guidelines for coronary artery bypass graft surgery: A report of the American College of Cardiology/ American Heart Association task force on Practice Guidelines (Committee to revise the 1991 Guidelines for Coronary Artery Bypass Graft Surgery) J. Am. Coll. Cardiol., October 1, 1999; 34(4): 1262 - 1347. [Full Text] [PDF]
|
|
|
|
|
|
J. M. Pearl, P. B. Manning, J. L. McNamara, M. M. Saucier, and D. W. Thomas Effect of modified ultrafiltration on plasma thromboxane B2, leukotriene B4, and endothelin-1 in infants undergoing cardiopulmonary bypass Ann. Thorac. Surg., October 1, 1999; 68(4): 1369 - 1375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Wan, J.-L. LeClerc, C.-H. Huynh, D. Schmartz, J.-M. DeSmet, A. P.C. Yim, and J.-L. Vincent DOES STEROID PRETREATMENT INCREASE ENDOTOXIN RELEASE DURING CLINICAL CARDIOPULMONARY BYPASS? J. Thorac. Cardiovasc. Surg., May 1, 1999; 117(5): 1004 - 1008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Picone, C. J. Lutz, C. Finck, D. Carney, L. A. Gatto, A. Paskanik, B. Searles, K. Snyder, and G. Nieman Multiple sequential insults cause post-pump syndrome Ann. Thorac. Surg., April 1, 1999; 67(4): 978 - 985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S T Baksaas, V Videm, T E Mollnes, S Tollofsrud, G Hetland, T Pedersen, and J L Svennevig Leucocyte filtration during cardiopulmonary bypass hardly changed leucocyte counts and did not influence myeloperoxidase, complement, cytokines or platelets Perfusion, December 1, 1998; 13(6): 429 - 436. [Abstract] [PDF]
|
|
|
|
|
|
G. Asimakopoulos and K. M. Taylor Effects of cardiopulmonary bypass on leukocyte and endothelial adhesion molecules Ann. Thorac. Surg., December 1, 1998; 66(6): 2135 - 2144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Steingrub Novel Insights Into the Pathogenesis and Therapy of Circulatory Shock Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 1998; 2(1): 31 - 45. [Abstract] [PDF]
|
|
|
|
|
|
Y. J. Gu, M. A. Mariani, W. van Oeveren, J. G. Grandjean, and P. W. Boonstra Reduction of the Inflammatory Response in Patients Undergoing Minimally Invasive Coronary Artery Bypass Grafting Ann. Thorac. Surg., February 1, 1998; 65(2): 420 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ashraf, Y. Tian, D. Cowan, A. Entress, P. G. Martin, and K. G. Watterson Release of Proinflammatory Cytokines During Pediatric Cardiopulmonary Bypass: Heparin-Bonded Versus Nonbonded Oxygenators Ann. Thorac. Surg., December 1, 1997; 64(6): 1790 - 1794. [Abstract] [Full Text]
|
|
|
|
|
|
S. Ashraf, Y. Tian, D. Cowan, U. Nair, R. Chatrath, N. R. Saunders, K. G. Watterson, and P. G. Martin ""Low-Dose"" Aprotinin Modifies Hemostasis but Not Proinflammatory Cytokine Release Ann. Thorac. Surg., January 1, 1997; 63(1): 68 - 73. [Abstract] [Full Text]
|
|
|
|
|
|
H. Mayumi, Q.-W. Zhang, A. Nakashima, M. Masuda, H. Kohno, Y. Kawachi, and H. Yasui Synergistic Immunosuppression Caused by High-Dose Methylprednisolone and Cardiopulmonary Bypass Ann. Thorac. Surg., January 1, 1997; 63(1): 129 - 137. [Abstract] [Full Text]
|
|
|
|
|
|
S. Wan, J.-L. LeClerc, and J.-L. Vincent Cytokine Responses to Cardiopulmonary Bypass: Lessons Learned From Cardiac Transplantation Ann. Thorac. Surg., January 1, 1997; 63(1): 269 - 276. [Abstract] [Full Text]
|
|
|
|
|
|
J. Butler, V. L. Pathi, R. D. Paton, R. W. Logan, K. J. D. MacArthur, M. P. G. Jamieson, and J. C. S. Pollock Acute-Phase Responses to Cardiopulmonary Bypass in Children Weighing Less Than 10 Kilograms Ann. Thorac. Surg., August 1, 1996; 62(2): 538 - 542. [Abstract] [Full Text]
|
|
|
|
|
|
J. Cremer, M. Martin, H. Redl, S. Bahrami, C. Abraham, T. Graeter, A. Haverich, G. Schlag, and H.-G. Borst Systemic Inflammatory Response Syndrome After Cardiac Operations Ann. Thorac. Surg., June 1, 1996; 61(6): 1714 - 1720. [Abstract] [Full Text]
|
|
|
|
|
|
S. Wan, J.-M. DeSmet, M. Antoine, M. Goldman, J.-L. Vincent, and J.-L. LeClerc Steroid Administration in Heart and Heart-Lung Transplantation: Is the Timing Adequate? Ann. Thorac. Surg., February 1, 1996; 61(2): 674 - 678. [Abstract] [Full Text]
|
|
|
|
|
|
G. E. Hill, A. Alonso, J. R. Spurzem, A. H. Stammers, and R. A. Robbins APROTININ AND METHYLPREDNISOLONE EQUALLY BLUNT CARDIOPULMONARY BYPASS-INDUCED INFLAMMATION IN HUMANS J. Thorac. Cardiovasc. Surg., December 1, 1995; 110(6): 1658 - 1662. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. H.T. Teoh, C. A. Bradley, J. Gauldie, and H. Burrows Steroid Inhibition of Cytokine-Mediated Vasodilation After Warm Heart Surgery Circulation, November 1, 1995; 92(9): 347 - 353. [Abstract] [Full Text]
|
|
|
|
|
|
R. M. Engelman, J. A. Rousou, J. E. Flack III, D. W. Deaton, R. Kalfin, and D. K. Das Influence of Steroids on Complement and Cytokine Generation After Cardiopulmonary Bypass Ann. Thorac. Surg., September 1, 1995; 60(3): 801 - 804. [Abstract] [Full Text]
|
|
|
|
|
|
E. J. Pesonen, R. Korpela, K. Peltola, M. Leijala, H. Sairanen, K. O. Raivio, P. Venge, and S. Andersson Regional generation of free oxygen radicals during cardiopulmonary bypass in children J. Thorac. Cardiovasc. Surg., September 1, 1995; 110(3): 768 - 773. [Abstract] [Full Text]
|
|
|
|
|
|
H. A. Hennein, H. Ebba, J. L. Rodriguez, S. H. Merrick, F. M. Keith, M. H. Bronstein, J. M. Leung, D. T. Mangano, L. J. Greenfield, and J. S. Rankin Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization J. Thorac. Cardiovasc. Surg., October 1, 1994; 108(4): 626 - 635. [Abstract] [Full Text]
|
|
|
|
|
|
D. Gadaleta, A. L. Fahey, M. Verma, W. Ko, K. H. Kreiger, O. W. Isom, and J. M. Davis Neutrophil leukotriene generation increases after cardiopulmonary bypass J. Thorac. Cardiovasc. Surg., October 1, 1994; 108(4): 642 - 647. [Abstract] [Full Text]
|
|
|
|
|
|
P. D. Cooper Inhibition by dexamethasone of the reperfusion phenomena in cardiopulmonary bypass J. Thorac. Cardiovasc. Surg., February 1, 1994; 107(2): 621 - 621. [Full Text]
|
|
|
|
|
|
N. E. Moat and P. D. MacNaughton Routine dexamethasone therapy for cardiac operations? J. Thorac. Cardiovasc. Surg., February 1, 1994; 107(2): 621 - 622. [Full Text]
|
|
|
|
|
|
P. W. Boonstra, Y. J. Gu, C. Akkerman, J. Haan, R. Huyzen, and W. van Oeveren Heparin coating of an extracorporeal circuit partly improves hemostasis after cardiopulmonary bypass J. Thorac. Cardiovasc. Surg., January 1, 1994; 107(1): 289 - 292. [Abstract] [Full Text]
|
|
|
|
|
|
P. Menasche, S. Haydar, J. Peynet, C. D. Buit, R. Merval, G. Bloch, A. Piwnica, and A. Tedgui A potential mechanism of vasodilation after warm heart surgery: The temperature-dependent release of cytokines J. Thorac. Cardiovasc. Surg., January 1, 1994; 107(1): 293 - 299. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
