HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pattison, C. W. Articles by Yacoub, M. Search for Related Content PubMed PubMed Citation Articles by Pattison, C. W. Articles by Yacoub, M.

The Journal of Thoracic and Cardiovascular Surgery, Vol 102, 766-773, Copyright © 1991 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Aortic counterpulsation for up to 28 days with autologous latissimus dorsi in sheep

CW Pattison, DV Cumming, A Williamson, DG Clayton-Jones, MJ Dunn, G Goldspink and M Yacoub
Department of Cardiac Surgery, Royal Brompton and National Heart Hospital, London, England.

This article reports the development and assessment of an entirely autologous extraaortic counterpulsation system using skeletal muscle (latissimus dorsi). The technique has been performed and assessed in 16 sheep to quantify the effectiveness of counterpulsation over periods up to 28 days and to optimize the stimulation regimens for muscle contraction and fiber-type transformation. Hemodynamic changes have been quantified by calculation of the endocardial viability ratio. This has shown an increase of between 12% and 89% for 28 days. The wide variety of increase observed has been related to the development of an optimum flap configuration. The technique of surface impedance monitoring of flap blood flow has allowed the start of electrical stimulation after 48 hours with the introduction of hemodynamic benefit (1:4 mode) during the process of fiber-type transformation (in situ training). Extraaortic counterpulsation with autologous latissimus dorsi has been shown to be effective and safe for as long as 28 days. It has not been associated with any thromboembolic or infective complications, which we attribute to the exclusion of any foreign material in the design.

This article has been cited by other articles:

				G. Bolotin, F. H. van der Veen, R. Lorusso, T. Wolf, R. Sachner, R. Shofti, J. J. Shreuder, and G. Uretzky Hemodynamic analysis of descending versus ascending aortomyoplasty, and comparison with intra-aortic balloon pump Eur. J. Cardiothorac. Surg., June 1, 2002; 21(6): 975 - 980. [Abstract] [Full Text] [PDF]

				G. Bolotin, T. Wolf, R. Shachner, F. H. van der Veen, R. Shofti, R. Lorusso, J. J. Shreuder, and G. Uretzky Hemodynamic evaluation of descending aortomyoplasty versus intra-aortic balloon pump performed in normal animals: an acute study Eur. J. Cardiothorac. Surg., February 1, 2001; 19(2): 174 - 178. [Abstract] [Full Text] [PDF]

				B. L. Cmolik, D. R. Thompson, J. T. Sherwood, A. S. Geha, and D. T. George Increased coronary artery blood flow with aortomyoplasty in chronic heart failure Ann. Thorac. Surg., January 1, 2001; 71(1): 284 - 289. [Abstract] [Full Text] [PDF]

				N. W. Guldner, P. Klapproth, M. Gro{beta}herr, M. Stephan, E. Rumpel, R. Noel, and H.-H. Sievers Clenbuterol-Supported Dynamic Training of Skeletal Muscle Ventricles Against Systemic Load : A Key for Powerful Circulatory Assist? Circulation, May 9, 2000; 101(18): 2213 - 2219. [Abstract] [Full Text] [PDF]

				G. Bolotin, T. Wolf, F. H. van der Veen, R. Shofti, R. Loruso, J. J. Shreuder, and G. Uretzky Acute descending aortomyoplasty induces coronary blood flow augmentation Ann. Thorac. Surg., November 1, 1999; 68(5): 1668 - 1675. [Abstract] [Full Text] [PDF]

				M P HAYWARD Dynamic cardiomyoplasty: time to wrap it up? Heart, September 1, 1999; 82(3): 263 - 264. [Full Text] [PDF]

				A. Hakami, W. P. Santamore, R. W. Stremel, G. Tobin, and V. E. Hjortdal Evaluation of stimulation parameters on aortomyoplasty, using Latissimus Dorsi muscle in a goat model: an acute study Eur. J. Cardiothorac. Surg., August 1, 1999; 16(2): 228 - 232. [Abstract] [Full Text] [PDF]

				D. R. Trumble and J. A. Magovern A permanent prosthesis for converting in situ muscle contractions into hydraulic power for cardiac assist J Appl Physiol, May 1, 1997; 82(5): 1704 - 1711. [Abstract] [Full Text] [PDF]

				M. Petrou, C. Bowles, and M. Yacoub Comparative study of the biomechanical performance of trained and untrained skeletal muscle Cardiovasc Res, March 1, 1997; 33(3): 583 - 592. [Abstract] [PDF]

				E. R. Soltero, D. H. Glaeser, L. H. Michael, C. J. Hartley, N. R. Earle, Z. Li, and G. M. Lawrie Hemodynamic Effects of Different Pacing Ratios in Chronic Dynamic Double Cardiomyoplasty Ann. Thorac. Surg., November 1, 1996; 62(5): 1380 - 1387. [Abstract] [Full Text]

				D. R. Flum, A. C. Cernaianu, R. Meada, L. A. Lee, K. Salartash, M. A. Grosso, R. L. Weiss, J. H. Cilley Jr, and A. J. DelRossi Descending Thoracic Aortomyoplasty: A Technique for Clinical Application Ann. Thorac. Surg., January 1, 1996; 61(1): 93 - 98. [Abstract] [Full Text]

				J.-C. Chachques, M. Radermercker, M. J. Tolan, E. I.C. Fischer, P. A. Grandjean, and A. F. Carpentier Aortomyoplasty Counterpulsation: Experimental Results and Early Clinical Experience Ann. Thorac. Surg., January 1, 1996; 61(1): 420 - 425. [Abstract] [Full Text]

				J. C. Cardone, P. D. Yoon, D. R. Trumble, and J. A. Magovern Regional Effects of Aortomyoplasty in Acute Ischemia Ann. Thorac. Surg., January 1, 1996; 61(1): 426 - 429. [Abstract] [Full Text]

				M. Takahashi, T. Misaki, G. Watanabe, H. Ohtake, Y. Tsunezuka, M. Wada, N. Sakakibara, Y. Matsunaga, M. Kawasuji, and Y. Watanabe Efficacy of a Skeletal Muscle-Powered Dynamic Patch: Part 1. Left Ventricular Assistance Ann. Thorac. Surg., February 1, 1995; 59(2): 305 - 312. [Abstract] [Full Text]