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The Journal of Thoracic and Cardiovascular Surgery, Vol 103, 295-306, Copyright © 1992 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
AL de Hoyos, GA Patterson, JR Maurer, JC Ramirez, JD Miller and TL Winton
Between November 1983 and March 1991, we performed 50 single and 40 double
lung transplants in 82 recipients. Early deaths occurred in six (13%)
single and in eight (21%) double lung transplant recipients. Late deaths
occurred in 11 (28%) single and in one (3%) double lung recipients.
Twenty-three of 37 (62%) single and 17 of 24 (71%) double lung transplant
recipients have survived at least 1 year after the operation. In patients
surviving at least 3 months after the operation (36 of 47 single lung
transplant [77%] and 28 of 37 double lung transplant recipients [76%]),
significant improvement occurred in arterial blood gases, pulmonary
function tests, and exercise capacity. During our initial experience,
airway anastomotic complications were the main cause of early morbidity and
mortality. With newer surgical techniques and improved perioperative care,
airway complications are now uncommon. Infectious complications, either
bacterial (Pseudomonas cepacia) or viral (cytomegalovirus), are now the
main cause of early mortality. Chronic rejection in the form of
obliterative bronchiolitis has become a frequent cause of late morbidity.
ARTICLES
Pulmonary transplantation. Early and late results. The Toronto Lung Transplant Group
Department of Surgery, University of Toronto, Ontario, Canada.
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