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The Journal of Thoracic and Cardiovascular Surgery, Vol 103, 314-325, Copyright © 1992 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
SH Keshavjee, F Yamazaki, H Yokomise, PF Cardoso, JB Mullen, AS Slutsky and GA Patterson
We have previously demonstrated that a low-potassium dextran solution
provides superior and more reliable preservation of lungs for 12 hours than
that provided by the commonly used Euro-Collins solution. This study was
designed to examine the individual contributions of dextran 40 and a low
(extracellular) potassium concentration to lung preservation. In a
randomized, blinded study using an in vivo canine single-lung transplant
model, lungs preserved with low-potassium dextran solution (K+, 4 mmol/L;
dextran 40, 20 gm/L) were compared to lungs preserved with low-potassium,
no-dextran solution (K+, 4 mmol/L) and high-potassium dextran solution (K+,
123 mmol/L; dextran 40, 20 gm/L). The lungs were assessed immediately and 3
days after transplantation. The low-potassium dextran solution provided
excellent immediate pulmonary function with little variability (arterial
oxygen tension, 519 +/- 12 mm Hg, measured on the transplanted lung alone,
inspired oxygen fraction = 1.0, n = 6). Removing the dextran 40 from the
flush solution (low-potassium group) led to a significant deterioration in
pulmonary function (arterial oxygen tension, 243 +/- 78 mm Hg, n = 6, p
less than 0.01). The high-potassium dextran solution provided extremely
poor preservation (arterial oxygen tension, 176 +/- 79 mm Hg; n = 6; p less
than 0.01). Two animals in this group died within 6 hours of operation.
Viability of the transplanted bronchus was significantly improved with the
two solutions containing dextran 40. These results indicate that dextran 40
and low potassium concentration both contribute significantly to the
uniformly excellent 12-hour lung preservation seen with the low-potassium
dextran solution.
ARTICLES
The role of dextran 40 and potassium in extended hypothermic lung preservation for transplantation
Division of Thoracic Surgery, University of Toronto, Ontario, Canada.
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|
|
|
|
|
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