HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Davies, S. W. Articles by Walesby, R. K. Search for Related Content PubMed PubMed Citation Articles by Davies, S. W. Articles by Walesby, R. K.

The Journal of Thoracic and Cardiovascular Surgery, Vol 105, 979-987, Copyright © 1993 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Time-course of free radical activity during coronary artery operations with cardiopulmonary bypass

SW Davies, JP Duffy, DG Wickens, SM Underwood, A Hill, MF Alladine, RO Feneck, TL Dormandy and RK Walesby
Cardiac Department, London Chest Hospital, United Kingdom.

Myocardial and pulmonary impairment after cardiopulmonary bypass may be caused by oxygen free radicals produced by reperfusion and by activated neutrophils. Free radical activity was assessed by assays for lipid peroxidation (thiobarbituric acid-reactive material) and phospholipid- esterified diene conjugation (18:2[9,11]/18:2[9,12] molar ratio) in 25 patients during coronary artery operations. Arterial blood samples were obtained before, during the ischemic period, and for 24 hours thereafter. There were no significant changes in free radical indices during the ischemic periods, but after cessation of bypass they increased significantly. Ten minutes after bypass thiobarbituric acid- reactive material rose from 96 (median; range 65 to 145) nmol/gm albumin to 138 (85 to 200) nmol/gm albumin (p < 0.001), and molar ratio rose from 2.23% (0.45% to 7.70%) to 2.51% (0.39% to 7.93%) (p < 0.02). Values of thiobarbituric acid-reactive material subsequently decreased, but molar ratio reached a peak at 4 hours after bypass, 2.64% (0.55% to 10.08%) (p < 0.001), thereafter returning to baseline. The postoperative increases in thiobarbituric acid-reactive material and in molar ratio were correlated (r = +0.53; p = 0.006). These increases in thiobarbituric acid-reactive material and in molar ratio were not related to age, preoperative left ventricular function, or the number of grafts performed. Increase in thiobarbituric acid-reactive material correlated with the duration of cardiopulmonary bypass (r = +0.43; p = 0.03). In 10 patients in whom cardiopulmonary bypass was performed using a bubble oxygenator, the increases in thiobarbituric acid- reactive material were significantly greater than in the 15 in whom a membrane oxygenator was used (p < 0.02). These data show that after apparently uncomplicated coronary operations with bypass there is an increase in lipid peroxidation and diene conjugation, indicating increased free radical activity. This increase varies between patients and does not relate to patient or surgical factors but may depend on the type of oxygenator employed during bypass.

This article has been cited by other articles:

				C. Berndt, C. H. Lillig, and A. Holmgren Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system Am J Physiol Heart Circ Physiol, March 1, 2007; 292(3): H1227 - H1236. [Abstract] [Full Text] [PDF]

				E. M. Knott, M.-G. Ryou, J. Sun, A. Heymann, A. B. Sharma, Y. Lei, M. Baig, R. T. Mallet, and A. H. Olivencia-Yurvati Pyruvate-fortified cardioplegia suppresses oxidative stress and enhances phosphorylation potential of arrested myocardium Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1123 - H1130. [Abstract] [Full Text] [PDF]

				C. R. Luyten, F. J. van Overveld, L. A. De Backer, A. M. Sadowska, I. E. Rodrigus, S. G. De Hert, and W. A. De Backer Antioxidant defence during cardiopulmonary bypass surgery Eur. J. Cardiothorac. Surg., April 1, 2005; 27(4): 611 - 616. [Abstract] [Full Text] [PDF]

				W.-J. P. van Boven, W. B. M. Gerritsen, P. Zanen, J. C. Grutters, H. P. A. van Dongen, A. Bernard, and L. P. H. J. Aarts Pneumoproteins as a Lung-Specific Biomarker of Alveolar Permeability in Conventional On-pump Coronary Artery Bypass Graft Surgery vs Mini-Extracorporeal Circuit: A Pilot Study Chest, April 1, 2005; 127(4): 1190 - 1195. [Abstract] [Full Text] [PDF]

				Y.-F. Chen, W.-C. Tsai, C.-C. Lin, L.-Y. Tsai, C.-S. Lee, C.-H. Huang, P.-C. Pan, and M.-L. Chen Effect of leukocyte depletion on endothelial cell activation and transendothelial migration of leukocytes during cardiopulmonary bypass Ann. Thorac. Surg., August 1, 2004; 78(2): 634 - 642. [Abstract] [Full Text] [PDF]

				W J van Boven, W B Gerritsen, F G Waanders, F J Haas, and L P Aarts Mini extracorporeal circuit for coronary artery bypass grafting: initial clinical and biochemical results: A comparison with conventional and off-pump coronary artery bypass grafts concerning global oxidative stress and alveolar function Perfusion, July 1, 2004; 19(4): 239 - 246. [Abstract] [PDF]

				L. Kubala, M. Ciz, J. Vondracek, J. Cerny, P. Nemec, P. Studenik, H. Cizova, and A. Lojek Perioperative and postoperative course of cytokines and the metabolic activity of neutrophils in human cardiac operations and heart transplantation J. Thorac. Cardiovasc. Surg., December 1, 2002; 124(6): 1122 - 1129. [Abstract] [Full Text]

				H. A. Hennein Inflammation After Cardiopulmonary Bypass: Therapy for the Postpump Syndrome Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2001; 5(3): 236 - 255. [Abstract] [PDF]

				M. Jahangiri, I. B. Kovacs, C. D. Ridler, G. M. Rees, and P. Gorog Coronary artery surgery is associated with different forms of atherogenic lipoprotein modifications Ann. Thorac. Surg., March 1, 1999; 67(3): 652 - 656. [Abstract] [Full Text] [PDF]

				Y. Chiba, K. Morioka, R. Muraoka, A. Ihaya, T. Kimura, T. Uesaka, T. Tsuda, and K. Matsuyama Effects of Depletion of Leukocytes and Platelets on Cardiac Dysfunction After Cardiopulmonary Bypass Ann. Thorac. Surg., January 1, 1998; 65(1): 107 - 113. [Abstract] [Full Text] [PDF]

				S. W. MacGowan, M. C. Regan, C. Malone, O. Sharkey, L. Young, T. F. Gorey, and A. E. Wood Superoxide Radical and Xanthine Oxidoreductase Activity in the Human Heart During Cardiac Operations Ann. Thorac. Surg., November 1, 1995; 60(5): 1289 - 1293. [Abstract] [Full Text]

				L. A. Pyles, J. E. Fortney, J. J. Kudlak, R. A. Gustafson, and S. Einzig Plasma antioxidant depletion after cardipulmonary bypass in operations for congenital heart disease J. Thorac. Cardiovasc. Surg., July 1, 1995; 110(1): 165 - 171. [Abstract] [Full Text]

				G. Valen, G. A Khoschsorur, S. M Almdahl, H. Esterbauer, and J. Vaage Lipid peroxidation in open-heart surgery Perfusion, July 1, 1994; 9(4): 277 - 283. [Abstract] [PDF]