JTCS Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Masayoshi Okada
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sakata, M.
Right arrow Articles by Yasufuku, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sakata, M.
Right arrow Articles by Yasufuku, M.

J Thorac Cardiovasc Surg 1998;115:1023-1027
© 1998 Mosby, Inc.

SURGERY FOR CONGENITAL HEART DISEASE

A New Artificial Placenta with a Centrifugal Pump: Long-Term Total Extrauterine Support of Goat Fetuses

Masahiro Sakata, MD, Katsuya Hisano, MD, Masayoshi Okada, MD, Masao Yasufuku, MD

From the Kobe University School of Medicine, Department of Surgery, Division II, Kobe, Japan.

Received for publication April 30, 1997. Revisions requested June 17, 1997; revisions received Nov. 11, 1997. Accepted for publication Nov. 11, 1997. Address for reprints: Masahiro Sakata, MD, Department of Surgery, Division II, Kobe University School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650, Japan.

Purpose: We tried long-term total extrauterine support of goat fetuses at high pump flow, which was pulsatile and synchronized with the cardiac cycle and at low oxygen tension in the umbilical artery and vein by use of the new artificial placenta. Method: This system consisted of an arteriovenous extracorporeal membrane oxygenation using umbilical artery and vein and a thermoregulated water bath. Five goat fetuses (125 ± 0.7 days of gestation, 2.0 ± 0.9 kg) were incubated in lactated Ringer's solution. Mean pump flow rate ranged from 113 ± 16 to 193 ± 13 ml/min/kg, and umbilical arterial oxygen tension was maintained at 20 ± 3 to 23 ± 5 mm Hg for five fetuses. Result: Blood gas analysis echocardiogram showed that fetal circulation and sufficient oxygen consumption could be maintained, and fetal extrauterine support conditions were made as similar as possible to physiologic circulatory conditions. We achieved long-term extrauterine support of goat fetuses up to 237 hours (mean 137 ± 58 hours). Conclusion: We believe that this system can be used for experimental models of the fetus and will come into clinical application for fetal extrauterine support systems and backup systems for fetal operations.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1998 by The American Association for Thoracic Surgery.