| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Thorac Cardiovasc Surg 2000;119:21-026
© 2000 Mosby, Inc.
GENERAL THORACIC SURGERY |
From the Thoracic Surgery Unita and the Division of Anesthesiology,b University Hospital of Geneva, and the Geneva Cancer Registry,c Geneva, Switzerland.
Address for reprints: Anastase Spiliopoulos, MD, Thoracic Surgery Unit, Department of Surgery, University Hospital of Geneva, rue Micheli-du-Crest 24, 1211 Geneva 14, Switzerland.
Objective And Methods: To characterize gender differences in lung cancer, we conducted a retrospective analysis including all patients undergoing surgery for non–small cell lung carcinoma in a single institution over a 20-year period.
Results: Compared with men (n = 839), women (n = 198) were more likely to be asymptomatic (32% vs 20%, P = .006), nonsmokers (27% vs 2%, P < .001), or light smokers (31 pack-years vs 52 pack-years; P < .001). Squamous cell carcinoma predominated in men (65%), and adenocarcinoma predominated in women (54%). Preoperative bronchoscopy contributed more frequently to a histologic diagnosis in men (69% vs 49% in women, P < .001), and fewer pneumonectomies were performed in women (22% vs 32% in men, P = .01). After multivariate Cox regression analysis, women survived longer than men (hazard ratio, 0.72; 95% confidence interval, 0.56-0.92; P = .009) independently of age, presence of symptoms, smoking habits, type of operation, histologic characteristics, and stage of disease. The protective effect linked to female sex was present in early-stage carcinoma (stage I and II) and absent in more advanced-stage carcinoma (stage III and IV).
Conclusions: This study emphasizes strong sex differences in presentation, management, and prognosis of patients with non–small cell lung cancer.
This article has been cited by other articles:
|
|
 |
|
  M. Y. Chang, S. J. Mentzer, Y. L. Colson, P. A. Linden, M. T. Jaklitsch, S. R. Lipsitz, and D. J. Sugarbaker Factors predicting poor survival after resection of stage IA non-small cell lung cancer. J. Thorac. Cardiovasc. Surg., October 1, 2007; 134(4): 850 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Wisnivesky and E. A. Halm Sex Differences in Lung Cancer Survival: Do Tumors Behave Differently in Elderly Women? J. Clin. Oncol., May 1, 2007; 25(13): 1705 - 1712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-H. Hsu, C.-S. Huang, H.-S. Hsu, W.-J. Huang, H.-C. Lee, B.-S. Huang, and M.-H. Huang Preoperative Serum Carcinoembryonic Antigen Level is a Prognostic Factor in Women With Early Non-Small-Cell Lung Cancer Ann. Thorac. Surg., February 1, 2007; 83(2): 419 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. V. Sequist, V. A. Joshi, P. A. Janne, A. Muzikansky, P. Fidias, M. Meyerson, D. A. Haber, R. Kucherlapati, B. E. Johnson, and T. J. Lynch Response to treatment and survival of patients with non-small cell lung cancer undergoing somatic EGFR mutation testing. Oncologist, January 1, 2007; 12(1): 90 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 International Early Lung Cancer Action Program Inv Women's Susceptibility to Tobacco Carcinogens and Survival After Diagnosis of Lung Cancer JAMA, July 12, 2006; 296(2): 180 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-K. Toh, F. Gao, W.-T. Lim, S.-S. Leong, K.-W. Fong, S.-P. Yap, A. A.L. Hsu, P. Eng, H.-N. Koong, A. Thirugnanam, et al. Never-Smokers With Lung Cancer: Epidemiologic Evidence of a Distinct Disease Entity J. Clin. Oncol., May 20, 2006; 24(15): 2245 - 2251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Doddoli, B. D'Journo, F. Le Pimpec-Barthes, A. Dujon, C. Foucault, P. Thomas, and M. Riquet Lung Cancer Invading the Chest Wall: A Plea for En-Bloc Resection but the Need for New Treatment Strategies Ann. Thorac. Surg., December 1, 2005; 80(6): 2032 - 2040. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-S. Hsu, C.-K. Wen, Y.-A. Tang, R.-K. Lin, W.-Y. Li, W.-H. Hsu, and Y.-C. Wang Promoter Hypermethylation Is the Predominant Mechanism in hMLH1 and hMSH2 Deregulation and Is a Poor Prognostic Factor in Nonsmoking Lung Cancer Clin. Cancer Res., August 1, 2005; 11(15): 5410 - 5416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Fu, T. Y. Kau, R. K. Severson, and G. P. Kalemkerian Lung Cancer in Women: Analysis of the National Surveillance, Epidemiology, and End Results Database Chest, March 1, 2005; 127(3): 768 - 777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Olak and Y. Colson Gender differences in lung cancer: Have we really come a long way, baby? J. Thorac. Cardiovasc. Surg., September 1, 2004; 128(3): 346 - 351. [Full Text] [PDF]
|
|
|
|
|
|
L. T. Nordquist, G. R. Simon, A. Cantor, W. M. Alberts, and G. Bepler Improved Survival in Never-Smokers vs Current Smokers With Primary Adenocarcinoma of the Lung Chest, August 1, 2004; 126(2): 347 - 351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Visbal, B. A. Williams, F. C. Nichols III, R. S. Marks, J. R. Jett, M.-C. Aubry, E. S. Edell, J. A. Wampfler, J. R. Molina, and P. Yang Gender differences in non-small-cell lung cancer survival: an analysis of 4,618 patients diagnosed between 1997 and 2002 Ann. Thorac. Surg., July 1, 2004; 78(1): 209 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Patel, P. B. Bach, and M. G. Kris Lung Cancer in US Women: A Contemporary Epidemic JAMA, April 14, 2004; 291(14): 1763 - 1768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Tammemagi, C. Neslund-Dudas, M. Simoff, and P. Kvale Smoking and Lung Cancer Survival: The Role of Comorbidity and Treatment Chest, January 1, 2004; 125(1): 27 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Moore, C. M. Mery, M. T. Jaklitsch, A. P. Estocin, R. Bueno, S. J. Swanson, D. J. Sugarbaker, and J. M. Lukanich Menopausal effects on presentation, treatment, and survival of women with non-small cell lung cancer Ann. Thorac. Surg., December 1, 2003; 76(6): 1789 - 1795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Alexiou, D. Beggs, P. Onyeaka, K. Kotidis, S. Ghosh, L. Beggs, D. N. Hopkinson, J. P. Duffy, W. E. Morgan, and G. Rocco Pneumonectomy for Stage I (T1N0 and T2N0) nonsmall cell lung cancer has potent, adverse impact on survival Ann. Thorac. Surg., October 1, 2003; 76(4): 1023 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Robert, J.-C. Pache, Y. Seium, M. de Perrot, and A. Spiliopoulos Pulmonary blastoma: report of five cases and identification of clinical features suggestive of the disease Eur. J. Cardiothorac. Surg., November 1, 2002; 22(5): 708 - 711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Radzikowska, P. Glaz, and K. Roszkowski Lung cancer in women: age, smoking, histology, performance status, stage, initial treatment and survival. Population-based study of 20 561 cases Ann. Onc., July 1, 2002; 13(7): 1087 - 1093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Martin, R. J. Ginsberg, E. S. Venkatraman, M. S. Bains, R. J. Downey, R. J. Korst, M. G. Kris, and V. W. Rusch Long-Term Results of Combined-Modality Therapy in Resectable Non-Small-Cell Lung Cancer J. Clin. Oncol., April 15, 2002; 20(8): 1989 - 1995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Thomas, C. Doddoli, X. Thirion, O. Ghez, M.-J. Payan-Defais, R. Giudicelli, and P. Fuentes Stage I non-small cell lung cancer: a pragmatic approach to prognosis after complete resection Ann. Thorac. Surg., April 1, 2002; 73(4): 1065 - 1070. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. P. Stabile, A. L. G. Davis, C. T. Gubish, T. M. Hopkins, J. D. Luketich, N. Christie, S. Finkelstein, and J. M. Siegfried Human Non-Small Cell Lung Tumors and Cells Derived from Normal Lung Express Both Estrogen Receptor {alpha} and {beta} and Show Biological Responses to Estrogen Cancer Res., April 1, 2002; 62(7): 2141 - 2150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Alexiou, C.V. P. Onyeaka, D. Beggs, R. Akar, L. Beggs, F. D. Salama, J. P. Duffy, and W. E. Morgan Do women live longer following lung resection for carcinoma? Eur. J. Cardiothorac. Surg., February 1, 2002; 21(2): 319 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Facciolo, G. Cardillo, M. Lopergolo, G. Pallone, F. Sera, and M. Martelli Chest wall invasion in non-small cell lung carcinoma: A rationale for en bloc resection J. Thorac. Cardiovasc. Surg., April 1, 2001; 121(4): 649 - 656. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
