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J Thorac Cardiovasc Surg 2000;119:566-574
© 2000 Mosby, Inc.

SURGERY FOR ACQUIRED CARDIOVASCULAR DISEASE

SODIUM NITROPRUSSIDE IN PATIENTS WITH COMPROMISED LEFT VENTRICULAR FUNCTION UNDERGOING CORONARY BYPASS: REDUCTION OF CARDIAC PROINFLAMMATORY SUBSTANCES

From the Department of Cardiovascular Surgery,^a University of Essen, Essen, Germany; Department of Cardiovascular Surgery,^c Department of Anesthesiology,^d and Department of Laboratory Medicine,^e German Heart Center, Munich; and Department of Physiology,^b University of Munich, Munich, Germany.

Supported by the Deutsche Forschungsgemeinschaft (MA 1731/3-1).

Address for reprints: Parwis Massoudy, MD, Department of Cardiovascular Surgery, University of Essen, Hufelandstr 55, 45147 Essen, Germany (E-mail: parwis.massoudy{at}uni-essen.de ).

Objective: The aim of the present study was to investigate whether the nitric oxide donor sodium nitroprusside can reduce the cardiac inflammatory response during coronary artery bypass grafting in patients with severely compromised left ventricular function.
Methods: Patients (n = 30) were assigned to receive placebo or sodium nitroprusside (0.5 µg · kg^–1 · min^–1) for the first 60 minutes of reperfusion. Interleukin 6, interleukin 8, and tumor necrosis factor levels; platelet adhesion molecule CD41 and CD62 levels; and CD11b on leukocytes were determined in the radial artery and coronary sinus before cardiopulmonary bypass and during reperfusion (1, 5, 10, 35, and 75 minutes).
Results: At 1 minute of reperfusion, coronary venous levels of CD41-positive polymorphonuclear leukocytes were 8% lower than arterial levels in the placebo group and 18% higher in the sodium nitroprusside group (P = .021). At 5 minutes of reperfusion, the respective levels were 29% and 1% for interleukin 6 (P = .015), –5% and 20% for CD41-positive monocytes (P = .032), and –2% and 16% for CD11b-positive monocytes (P = .038). At 10 minutes of reperfusion, these levels were –14% and 21% for CD41-positive monocytes (P = .006). At 35 minutes of reperfusion, these levels were –13% and 7% for CD41-positive monocytes (P = .017), –41% and 23% for CD11b-positive monocytes (P = .001), and 7% and 25% for CD62-positive platelets (P = .041). At 75 minutes of reperfusion, the levels were 15% and –7% for tumor necrosis factor (P = .025) and –10% and 10% for CD62-positive platelets (P = .041).
Conclusions: Transcardiac production of proinflammatory cytokines is reduced in patients undergoing coronary artery bypass grafting treated with the nitric oxide donor sodium nitroprusside. At the same time, less activated leukocytes and platelets are retained in the coronary circulation.

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