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Eugene H. Blackstone
Bruce W. Lytle
John H. Arnold
Delos M. Cosgrove
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J Thorac Cardiovasc Surg 2000;119:963-974
© 2000 The American Association for Thoracic Surgery


Surgery For Acquired Cardiovascular Disease

Aortic valve replacement: Is valve size important?

Benjamin Medalion, MDa, Eugene H. Blackstone, MDa,b, Bruce W. Lytle, MDa, Jennifer White, MSb, John H. Arnold, MDa, Delos M. Cosgrove, MDa

From the Department of Thoracic and Cardiovascular Surgerya and the Department of Biostatistics and Epidemiology,b The Cleveland Clinic Foundation, Cleveland, Ohio.

Address for reprints: Bruce W. Lytle, MD, Department of Thoracic and Cardiovascular Surgery, 9500 Euclid Ave, Desk F25, Cleveland, OH 44195 (E-mail: lytleb{at}ccf.org ).

Objective: We sought to determine whether aortic prosthesis size adversely influences survival after aortic valve replacement.
Methods: A total of 892 adults receiving a mechanical (n = 346), pericardial (n = 463), or allograft (n = 83) valve for aortic stenosis were observed for up to 20 years (mean, 5.0 ± 3.9 years) after primary isolated aortic valve replacement. We used multivariable propensity scores to adjust for valve selection factors, multivariable hazard function analyses to identify risk factors for all-cause mortality, and bootstrap resampling to quantify the reliability of the results.
Results: Twenty-five percent of patients had indexed internal orifice areas of less than 1.5 cm2/m2 and more than 2 SDs (Z-value) below predicted normal aortic valve size. Mechanical valve orifices were smaller (1.3 ± 0.29 cm2/m2, Z = –2.2 ± 1.16) than pericardial (1.9 ± 0.36 cm2/m2, Z = –0.40 ± 1.01) or allograft valves (2.1 ± 0.50, Z = 0.24 ± 1.17). The overall survival was 98%, 96%, 86%, 69%, and 49% at 30 days and 1, 5, 10, and 15 years postoperatively. Univariably, survival was weakly and inversely related to manufacturer valve size (P = .16) and internal orifice diameter (P = .2) but completely unrelated to indexed valve area (P = .6) or Z-value (P = .8). These, and univariable differences among valve types (P = .004), were accounted for by different prevalences in patient risk factors and not by valve size or type per se. Bootstrap resampling indicated that these findings had a less than 15% chance of being incorrect.
Conclusions: Survival after aortic valve replacement is strongly related to patient risk factors but appears not to be adversely affected by moderate patient-prosthesis mismatch (down to about 4 SDs below normal). Aortic root enlargement to accommodate a large prosthesis may be required in few situations.




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