| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Thorac Cardiovasc Surg 2000;120:29-38
© 2000 The American Association for Thoracic Surgery
CARDIOTHORACIC TRANSPLANTATION |
From the Department of Surgery,a Duke University Medical Center, Durham, NC; the Departments of Surgery, Pediatrics, and Immunology,c Mayo Foundation, Rochester, Minn; and Nextran,b Princeton Forrestal Center, Princeton, NJ.
Supported by National Institutes of Health grants HL50985 and HL52297 and by Nextran. Christine L. Lau is a recipient of the International Society for Heart and Lung Transplantation Research Fellowship.
Address for reprints: R. Duane Davis, MD, Department of General and Thoracic Surgery, Box 3864, Duke University Medical Center, Durham, NC 27710 (E-mail: davis053{at}mc.duke.edu ).
Objective: Pulmonary transplantation has become the preferred treatment for end-stage lung disease, but application of the procedure is limited because of a paucity of donors. One way to solve donor limitations is to use animal organs as a donor source or xenotransplantation. The current barrier to pulmonary xenotransplantation is the rapid failure of the pulmonary xenograft. Although antibodies are known to play a role in heart and kidney xenograft rejection, their involvement in lung dysfunction is less defined. This project was designed to define the role of antibodies in pulmonary graft rejection in a pig-to-baboon model.
Methods: Orthotopic transgenic swine left lung transplants were performed in baboons depleted of antibodies by one of three techniques before transplantation: (1) ex vivo swine kidney perfusion, (2) total immunoglobulin-depleting column perfusion, and (3) ex vivo swine lung perfusion. Results were compared with those of transgenic swine lung transplants in unmodified baboons.
Results: All three techniques of antibody removal resulted in depletion of xenoreactive antibodies. Only pretransplantation lung perfusion improved pulmonary xenograft function compared with lung transplantation in unmodified baboons.
Conclusions: The pathogenesis of pulmonary injury in a swine-to-primate transplant model is different from that in renal and cardiac xenografts. Depletion of antibodies alone does not have a beneficial effect and may actually be detrimental.
This article has been cited by other articles:
|
|
 |
|
  B. P. Griffith, M. Haddad, and R. S. Poston Immunobiology of Heart and Heart-Lung Transplantation Card. Surg. Adult, January 1, 2008; 3(2008): 1513 - 1538. [Full Text]
|
|
|
|
 |
|
 B.-N. H. Nguyen, A. M. Azimzadeh, T. Zhang, G. Wu, H.-J. Shuurman, D. H. Sachs, D. Ayares, J. S. Allan, and R. N. Pierson III Life-supporting function of genetically modified swine lungs in baboons J. Thorac. Cardiovasc. Surg., May 1, 2007; 133(5): 1354 - 1363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Kang, G. Lee, J. Y. Kim, S. H. Lee, H. C. Wi, P. G. Hwang, D. H. Chung, and Y. T. Kim Pre-treatment of donor with 1-deamino-8-D-arginine vasopressin could alleviate early failure of porcine xenograft in a cobra venom factor treated canine recipient Eur. J. Cardiothorac. Surg., July 1, 2005; 28(1): 149 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. P. Griffith and R. S. Poston Immunobiology of Heart and Heart-Lung Transplantation Card. Surg. Adult, January 1, 2003; 2(2003): 1403 - 1426. [Full Text]
|
|
|
|
 |
|
 S. Pfeiffer, G. L. Zorn III, S. Kelishadi, R. Oriol, P. Wolf, R. N. Pierson III, and A. M. Azimzadeh Role of anti-Gal{alpha}1,3Gal and anti-platelet antibodies in hyperacute rejection of pig lung by human blood Ann. Thorac. Surg., November 1, 2001; 72(5): 1681 - 1690. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
