HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Alfred C. Nicolosi John G. Markley Gordon N. Olinger Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nicolosi, A. C. Articles by Olinger, G. N. Search for Related Content PubMed PubMed Citation Articles by Nicolosi, A. C. Articles by Olinger, G. N. Related Collections Cardiac - pharmacology Myocardial protection

J Thorac Cardiovasc Surg 2002;124:57-62
© 2002 The American Association for Thoracic Surgery

Cardiopulmonary Support and Physiology (CSP)

Gadolinium attenuates regional stunning in the canine heart in vivo

From the Divisions of Cardiothoracic Surgery^a and Biostatistics,^b The Medical College of Wisconsin, Milwaukee, Wis.

Received for publication Sept 18, 2001. Revisions requested Nov 19, 2001; revisions received Dec 27, 2001. Accepted for publication Dec 28, 2001. Address for reprints: Alfred C. Nicolosi, MD, Division of Cardiothoracic Surgery, Froedtert Memorial Lutheran Hospital, 9200 W Wisconsin Ave, Milwaukee, WI 53226 (E-mail: nicolosi{at}mcw.edu).

Objective: Gadolinium, a lanthanide cation, ameliorates pathophysiologic features of both heart failure and cardiac arrhythmias. We have shown, in an in vitro model, that gadolinium blocks stretch-induced contractile dysfunction in both normal and stunned myocardium. The present study tested the hypothesis that gadolinium would also attenuate regional myocardial stunning in an in vivo model.
Methods: Mongrel dogs (n = 13) were subjected to regional myocardial ischemia (occlusion of the left anterior descending coronary artery) for 15 minutes, followed by reperfusion for 180 minutes. Intravenous gadolinium (500 µmol) was given to 7 dogs before ischemia; no gadolinium was given to control animals. Regional contractile function was assessed serially by means of both systolic shortening (percentage) and regional preload recruitable stroke work.
Results: Administration of gadolinium before ischemia had no effect on heart rate, arterial blood pressure, stroke volume, or regional contractile function. Ischemia resulted in paradoxical systolic bulging in both groups. After 180 minutes of reperfusion, systolic shortening was enhanced in gadolinium-treated animals compared with that in control animals (10.9% ± 1.5% vs 2.4% ± 1.7%, P = .003). Both the slope and x-axis intercept of regional preload recruitable stroke work returned to preischemic values in treated animals but remained abnormal in control animals.
Conclusions: These data confirm that gadolinium attenuates regional myocardial stunning in vivo. Gadolinium may cause peripheral vasodilatation but does not appear to exert positive inotropic effects on the normal canine heart. The mechanism underlying gadolinium-mediated effects on stunned myocardium remains undefined, but this study suggests that use of gadolinium may represent a novel adjunct to current cardioprotective strategies.

This article has been cited by other articles:

				S. M. Mosca Cardioprotective effects of stretch are mediated by activation of sarcolemmal, not mitochondrial, ATP-sensitive potassium channels Am J Physiol Heart Circ Physiol, August 1, 2007; 293(2): H1007 - H1012. [Abstract] [Full Text] [PDF]

				K. Matsukawa, T. Nakamoto, and A. Inomoto Gadolinium does not blunt the cardiovascular responses at the onset of voluntary static exercise in cats: a predominant role of central command Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H121 - H129. [Abstract] [Full Text] [PDF]

				A. Sarkis, G. Badaoui, and V. A. Jebara Indications for gadolinium for coronary angiography J. Thorac. Cardiovasc. Surg., May 1, 2003; 125(5): 1170 - 1170. [Full Text] [PDF]

				A. Nicolosi Reply J. Thorac. Cardiovasc. Surg., May 1, 2003; 125(5): 1170 - 1171. [Full Text] [PDF]