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J Thorac Cardiovasc Surg 2005;129:831-837
© 2005 The American Association for Thoracic Surgery

Evolving Technology

Off-pump replacement of the pulmonary valve in large right ventricular outflow tracts: A hybrid approach

^a Service de Cardiologie Pédiatrique, Hôpital Necker Enfants Malades, Paris, France
^b Institut National de la Santé et de la Recherche Médicale EMIU 0016, Faculté de Necker Enfants Malades, Paris, France
^c Cardiothoracic Unit, Great Ormond Street Hospital, London, United Kingdom

Received for publication August 31, 2004; revisions received October 19, 2004; accepted for publication October 28, 2004.

^_* Address for reprints: Younes Boudjemline, MD, Service de Cardiologie Pédiatrique, Hôpital Necker Enfants Malades, 149 rue de Sèvres, 75015 Paris Cedex, France (E-mail: younes.boudjemline{at}nck.ap-hop-paris.fr).

BACKGROUND: Percutaneous pulmonary valve replacement has recently been introduced and is under investigation in humans. This technique is, however, limited to patients with a right ventricular outflow tract that does not exceed 22 mm in diameter. We report our experience of off-pump pulmonary valve replacement using a hybrid approach in animals with large right ventricular outflow tracts.

METHODS: Eight ewes were included in the protocol and were equally divided into 2 groups. A left thoracotomy was first performed, and the main pulmonary artery was banded by using 2 radiopaque rings with a diameter of 18 mm that allowed for further pulmonary valve replacement. We then intended to implant a valved stent either percutaneously (group 1) or through a transventricular approach (group 2). All animals were killed after valve implantation. The operation allowed the pulmonary diameter to be reduced from 30 to 17.6 mm.

RESULTS: The right ventricular pressure did not significantly increase after reduction of the pulmonary artery diameter (25 vs 36 mm Hg). Subsequent pulmonary valve replacement through a percutaneous or a transventricular approach was always possible without any requirement for extracorporeal circulation. All devices were successfully delivered inside the pulmonary artery banding and were functioning perfectly at early evaluation.

CONCLUSIONS: Implantation of a pulmonary valve is possible in ewes through a hybrid approach when the right ventricular outflow tract exceeds 22 mm in diameter. This involves both surgeons and interventionists and allows for a staged procedure in which the valvulation is performed percutaneously or, for a combined hybrid approach, in which the valve is implanted off pump transventricularly during the same operation.

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