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J Thorac Cardiovasc Surg 2005;130:433-437
© 2005 The American Association for Thoracic Surgery

General Thoracic Surgery

Limited mediastinal lymph node dissection for non-small cell lung cancer according to intraoperative histologic examinations

Tatsuya Yoshimasu, MD, PhD a , * , Shinichiro Miyoshi, MD, PhD b , Shoji Oura, MD, PhD a , Issei Hirai, MD a , Yozo Kokawa, MD a , Yoshitaka Okamura, MD, PhD a

a Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University, Wakayama, Japan
b Department of Cardio Thoracic Surgery, Dokkyo University School of Medicine, Tochigi, Japan.

Received for publication August 1, 2004; revisions received January 24, 2005; accepted for publication February 10, 2005.

* Address for reprints: Tatsuya Yoshimasu, MD, PhD, Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University, 811-1, Kimiidera, Wakayama, Wakayama 641-8509, Japan. (Email: yositatu{at}mail.wakayama-med.ac.jp).

BACKGROUND: Although radioisotopic procedures are commonly used to detect sentinel lymph nodes in breast cancer surgery, these procedures are often problematic and not necessarily suitable for lung cancer surgery.

METHODS: Our previous study revealed that the mediastinal sentinel lymph node, defined as the regional mediastinal lymph node, consisted of nodes 2, 3, or 4 in right upper lobe cancers; 3, 7, or 8 in right lower lobe cancers; 4, 5, or 7 in left upper lobe cancers; and 4, 7, or 8 in left lower lobe cancers. On the basis of these findings, we pathologically investigated one representative lymph node at each of the 3 levels dissected during surgical intervention in 69 patients with non-small cell lung cancer from September 1993 through December 2002. Fifty-eight patients with lung cancer underwent lobectomies with limited mediastinal lymph node dissection according to this strategy.

RESULTS: Mediastinal lymph node recurrence was observed in only one patient during 41 ± 25 months (maximum, 98 months) of follow-up. The cancer-specific 5-year survivals were 96.6% in patients with pathologic stage IA disease (n = 31) and 67.4% in patients with stage IB disease (n = 16).

CONCLUSION: These results suggested that limited mediastinal lymph node dissection is applicable to patients with non-small cell lung cancer whose regional mediastinal lymph nodes are not metastatic.


Related Article

Limited mediastinal lymph node dissection for non-small cell lung cancer according to intraoperative histologic examinations
Tatsuya Yoshimasu, Shinichiro Miyoshi, Shoji Oura, Issei Hirai, Yozo Kokawa, and Yoshitaka Okamura
J. Thorac. Cardiovasc. Surg. 2005 130: 433-437. [Abstract] [Full Text] [PDF]



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