HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Peng Zhang Mark B. Ratcliffe Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Guccione, J. M. Articles by Ratcliffe, M. B. Search for Related Content PubMed PubMed Citation Articles by Guccione, J. M. Articles by Ratcliffe, M. B. Related Collections Cardiac - physiology Congestive Heart Failure Coronary disease Myocardial infarction

J Thorac Cardiovasc Surg 2006;131:579-586
© 2006 The American Association for Thoracic Surgery

Surgery for Acquired Cardiovascular Disease

The effect of anteroapical aneurysm plication on end-systolic three-dimensional strain in the sheep: A magnetic resonance imaging tagging study

^a Department of Surgery, University of California, San Francisco
^c Department of Bioengineering, University of California, San Francisco
^e Department of Anesthesia, University of California, San Francisco
^f Department of Radiology, University of California, San Francisco
^b Department of Veterans Affairs Medical Center, San Francisco, Calif
^d Laboratory of Cardiac Energetics, National Institutes of Health–National Heart Lung and Blood Institute, Bethesda, Md

Received for publication January 20, 2005; revisions received July 11, 2005; accepted for publication July 19, 2005.

^_* Address for reprints: Julius M. Guccione, MD, Division of Surgical Services (112D), Department of Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121 (Email: Julius.Guccione{at}med.va.gov).

OBJECTIVES: Although repair of left ventricular aneurysm has been extensively studied, its effect on regional ventricular function remains unclear. The primary goal of this study was to quantify the effect of anteroapical aneurysm plication on systolic deformation in noninfarcted adjacent (border zone) and remote left ventricular regions in sheep.

METHODS: Eight sheep underwent anteroapical myocardial infarction (25% of left ventricular mass). Ten weeks later, animals underwent aneurysm plication. Two and 6 weeks after this operation, animals underwent magnetic resonance imaging with tissue tagging in multiple short-axis and long-axis slices. Fully 3-dimensional strain analyses were performed. All 6 end-systolic strain components were compared at midwall in the border zone of the aneurysm or repair and in regions 1 cm, 2 cm, and 3 cm below the valves.

RESULTS: Circumferential shortening progressively increases from before plication to 2 weeks after plication to 6 weeks after plication toward the border zone. The effect on circumferential shortening is most pronounced in the anterior wall and septum. The biggest change is from 2 to 6 weeks after plication (from 4.3% to 11.3% in anterior wall, P < .0001; from 3.5% to 6.5% in septum, P < .0007). Longitudinal shortening is decreased at 2 weeks after plication but then returns to baseline (with slight improvement in the border zone) at 6 weeks after plication.

CONCLUSIONS: Repair of left ventricular aneurysm significantly increases systolic circumferential shortening at the border zone in sheep.

This article has been cited by other articles:

				J. C. Walker, M. B. Ratcliffe, P. Zhang, A. W. Wallace, E. W. Hsu, D. A. Saloner, and J. M. Guccione Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysm. J. Thorac. Cardiovasc. Surg., May 1, 2008; 135(5): 1094 - 1102.e2. [Abstract] [Full Text] [PDF]

				P. Zhang, J. M. Guccione, S. I. Nicholas, J. C. Walker, P. C. Crawford, A. Shamal, G. Acevedo-Bolton, M. A. Guttman, C. Ozturk, E. R. McVeigh, et al. Endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm increases systolic circumferential shortening in sheep. J. Thorac. Cardiovasc. Surg., October 1, 2007; 134(4): 1017 - 1024.e1. [Abstract] [Full Text] [PDF]