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J Thorac Cardiovasc Surg 2007;134:378-385
© 2007 The American Association for Thoracic Surgery

General Thoracic Surgery

Lymph node involvement in advanced gastroesophageal junction adenocarcinoma

Corrado Pedrazzani, MDa, Giovanni de Manzoni, MDb,*, Daniele Marrelli, MDa, Simone Giacopuzzi, MDb, Giovanni Corso, MDa, Anna Maria Minicozzi, MDb, Bernardino Rampone, MDa, Franco Roviello, MDa

a Department of Human Pathology and Oncology, Unit of Surgical Oncology, University of Siena, Siena, Italy
b Department of General Surgery, University of Verona, Verona, Italy.

Received for publication September 18, 2006; revisions received January 24, 2007; accepted for publication March 8, 2007.

* Address for reprints: Giovanni de Manzoni, MD, Via Franchetti 6, 57100 Verona, Italy. (Email: gdemanzon{at}mail.univr.it).

Objective: The prognosis of gastroesophageal junction adenocarcinoma is unquestionably related to the extent of nodal involvement; nonetheless, few studies deal with the pattern of lymph node spread and specifically analyze the prognostic value of the site of metastasis. The present study was aimed at evaluating these key aspects in advanced gastroesophageal junction adenocarcinoma.

Methods: Of 219 patients consecutively operated on for gastroesophageal junction adenocarcinoma at the Department of General Surgery and Surgical Oncology, University of Siena, and at the Department of General Surgery, University of Verona, 143 pT2-4 tumors not submitted to prior chemoradiation were analyzed according to the Japanese Gastric Cancer Association pN staging system.

Results: The majority of patients were given diagnoses of nodal metastases (77.6%). The mean number (P = .076) and the percentage of patients with pN+ disease (P = .022) progressively increased from Siewert type I to type III tumors. Abdominal nodes were involved in all but 1 of the patients with pN+ disease; conversely, nodal metastases into the chest were 46.2% for type I, 29.5% for type II, and 9.3% for type III tumors. Survival analysis showed virtually no chance of recovery for patients with more than 6 metastatic nodes or lymph nodes located beyond the first tier.

Conclusions: In advanced gastroesophageal junction adenocarcinoma, the high frequency of nodal metastases and the related unfavorable long-term outcome achieved by means of surgical intervention alone are indicative of the need for aggressive multimodal treatment along with surgical intervention to improve long-term results.

Abbreviations and Acronyms GEJ = gastroesophageal junction; JGCA = Japanese Gastric Cancer Association






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