HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tyers, G. F. Articles by Waldhausen, J. A. Search for Related Content PubMed PubMed Citation Articles by Tyers, G. F. Articles by Waldhausen, J. A.

The Journal of Thoracic and Cardiovascular Surgery, Vol 69, 190-195, Copyright © 1975 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

The mechanism of myocardial protection from ischemic arrest by intracoronary tetrodotoxin administration

GF Tyers, GJ Todd, JR Neely and JA Waldhausen

Intracoronary injection of 14 mcg. of tetrodotoxin into the ischemic isolated rat heart resulted in immediate cessation of mechanical activity. Upon reperfusion with oxygenated, modified Krebs-Henseleit bicarbonate buffer in a modified Langendorff apparatus, all hearts recovered normal rate, rtythm, and contractile vigor after up to 60 minutes of ischemia. In contrast, all hearts not administered tetrodotoxin showed bradycardia, irregular rhythm, and weak contraction upon reperfusion after 30 and 45 minutes of ischemia; after 60 minutes, no mechanical activity was evident. The improved cardiac function following ischemia in the tetrodotoxin-treated hearts was associated with persistence of normal adenosine triphosphate (ATP) levels after up to 30 minutes of ischemia and normal or elevated creatine phosphate (CP) levels after up to 60 minutes of ischemia. On the other hand, ATP and CP levels progressively declined to reach 50 per cent of normal values after 30 minutes in the ischemic hearts without tetrodotoxin. These findings indicate that postarrest ATP and CP levels play an important role in myocardial recovery after ischemic arrest.

This article has been cited by other articles:

				A. K. Snabaitis, M. J. Shattock, and D. J. Chambers Comparison of Polarized and Depolarized Arrest in the Isolated Rat Heart for Long-term Preservation Circulation, November 4, 1997; 96(9): 3148 - 3156. [Abstract] [Full Text]

				S. L. Maskal, N. M. Cohen, P.-W. Hsia, A. S. Wechsler, and R. J. Damiano Jr. HYPERPOLARIZED CARDIAC ARREST WITH A POTASSIUM-CHANNEL OPENER, APRIKALIM J. Thorac. Cardiovasc. Surg., October 1, 1995; 110(4): 1083 - 1095. [Abstract] [Full Text]

				N. M. Cohen, R. J. Damiano Jr, and A. S. Wechsler Is There an Alternative to Potassium Arrest? Ann. Thorac. Surg., September 1, 1995; 60(3): 858 - 863. [Abstract] [Full Text]