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The Journal of Thoracic and Cardiovascular Surgery, Vol 69, 306-314, Copyright © 1975 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Hypoglycemic coma associated with benign pleural mesothelioma

R Nelson, SO Burman, R Kiani, BS Chertow, J Shah and I Cantave

A case of hypoglycemic coma and benign pleural mesothelioma is described. Serum insulin levels, as measured by insulin radioimmunoassay, were appropriately suppressed and consistent with hypoglycemia. Assay of the tumor showed insulin to be undectable. The mechanisms for hypoglycemia probably included increased glucose consumption by the tumor and, more important, the inhibition of lipolysis and hepatic gluconegenesis caused by tumor release of L- tryptophan and its metabolites and/or possibly nonsuppressible insulin- like activity, soluble in acid-ethanol(NSILA-s).


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Copyright © 1975 by The American Association for Thoracic Surgery.