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The Journal of Thoracic and Cardiovascular Surgery, Vol 69, 421-428, Copyright © 1975 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Neurogenic influences on the coronary vascular response to ischemia in the awake dog

RJ Bache, FR Cobb, PA Ebert and JC Greenfield

The influence of the nervous system on the response of the coronary vessels to ischemia was evaluated by observing the reactive hyperemia subsequent to a 10 second occlusion of the left circumflex coronary artery in 19 awake dogs. Sympathectomy produced by pretreatment with 6- hydroxydopamine, chronic total surgical cardiac denervation, beta- adrenergic blockade with propranolol, and alpha blockade with phentolamine did not significantly after the reactive hyperemic response. Thus cardiac denervation did not impair the ability of the coronary vasculature to respond to a brief ischemic stimulus.




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Copyright © 1975 by The American Association for Thoracic Surgery.