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The Journal of Thoracic and Cardiovascular Surgery, Vol 70, 644-655, Copyright © 1975 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Platelets, hemostasis, and thromboembolism during treatment of acute respiratory insufficiency with extracorporeal membrane oxygenation

D Heiden, CH Mielke Jr, R Rodvien and JD Hill

Twenty-eight patients were supported with long-term extracorporeal membrane oxygenation as a treatment for acute respiratory insufficiency. Clinical, laboratory, and autopsy data concerning platelets, hemostasis, and thromboembolic disease are presented for the periods during and after bypass. During bypass, a "foreign-surface coagulopathy" was encountered which consisted of abnormal bleeding plus frequent, generalized, small and large vessel thromboembolic events. The abnormal bleeding is attributed to heparin, thrombocytopenia, and a qualitative platelet defect. Possible causes of the thromboembolic events including disseminated intravascular coagulation are also discussed, and speculations are offered concerning clinical management and directions for future investigation.


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E. G. Wittels, R. D. Siegel, and E. M. Mazur
Thrombocytopenia in the Intensive Care Unit Setting
J Intensive Care Med, September 1, 1990; 5(5): 224 - 240.
[Abstract] [PDF]


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Copyright © 1975 by The American Association for Thoracic Surgery.