HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Laufer, N. Articles by Borman, J. B. Search for Related Content PubMed PubMed Citation Articles by Laufer, N. Articles by Borman, J. B.

The Journal of Thoracic and Cardiovascular Surgery, Vol 70, 727-731, Copyright © 1975 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

The influence of cardiopulmonary bypass on the size of human platelets

N Laufer, G Merin, NB Grover, B Pessachowicz and JB Borman

Large and small platelets are present in the bloodstream in nearly equal proportions and comprise about 30 per cent of the normal platelet population. The assumption that cardiopulmonary bypass may alter this platelet population distribution was investigated. Platelet volume distribution curves during and after cardiopulmonary bypass were examined in 12 patients undergoing various intracardiac operation by an electronic particle-sizing apparatus based on the Coulter counter. Mean platelet volume (MPV) was 8.6 +/- 0.7 cubic microns prior to cardiopulmonary bypass. Ten minutes after commencement of cardiopulmonary bypass the MPV decreased to 85 per cent of control levels. A further decrease, reaching a plateau at 75 per cent of prebypass MPV, was reached after 50 minutes on bypass. MPV returned to 87 per cent of prebypass levels 2 hours after discontinuation of cardiopulmonary bypass. Since it is known that platelet count is markedly reduced on cardiopulmonary bypass, a simultaneous 25 per cent decrease in MPV can be explained only by a highly selective disappearance of the large platelets from the circulation. As the larger platelets are younger and functionally more potent than the smaller ones, the selective disappearance of large platelets may thus provide an explanation for the observed alteration in platelet adhesiveness caused by cardiopulmonary bypass.

This article has been cited by other articles:

				J. W. Hammon Extracorporeal Circulation: The Response of Humoral and Cellular Elements of Blood to Extracorporeal Circulation Card. Surg. Adult, January 1, 2008; 3(2008): 370 - 389. [Full Text]

				L. H. Edmunds Jr. and R. W. Colman Extracorporeal Circulation: Thrombosis and Bleeding Card. Surg. Adult, January 1, 2003; 2(2003): 338 - 348. [Full Text]

				J. A. Hyde, J. A Chinn, and T. R Graham Platelets and cardiopulmonary bypass Perfusion, December 1, 1998; 13(6): 389 - 407. [PDF]

				P. Kesteven Haemostatic changes during cardiopulmonary bypass Perfusion, January 1, 1990; 5(1_suppl): 9 - 19. [PDF]

				D.T. Pearson and B. McArdle Haemocompatibility of membrane and bubble oxygenators Perfusion, January 1, 1989; 4(1): 9 - 24. [Abstract] [PDF]

				C. Blauth, A. Brady, J. Arnold, J. Brannan, W. Schulenburg, R. Frackowiak, and K. Taylor A double blind clinical trial of Iloprost during cardiopulmonary bypass Perfusion, October 1, 1987; 2(4): 271 - 276. [Abstract] [PDF]