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The Journal of Thoracic and Cardiovascular Surgery, Vol 71, 179-186, Copyright © 1976 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Evaluation of aortic valve replacement with a porcine xenograft without long-term anticoagulation

RD Pipkin, WS Buch and TJ Fogarty

From June, 1971, through November, 1974, 75 patients underwent aortic valve replacement with a Hancock "Stabilized Glutaraldehyde Process" porcine xenograft. Patients who underwent multiple valve replacements are not included in the study. Thirty-nine per cent of the patients had procedures for associated lesions or for removal of a Starr-Edwards prosthesis. The operative mortality rate was 6.7 per cent. Six patients died in the late postoperative period. Only one death was thought to be secondary to a valve-related problem. Actuarial analysis predicts 84 per cent survival at 3 years. Three patients initially received long- term antithromboembolic therapy. There have been three suspected or documented thromboembolic episodes (0.24 per cent per patient-month). Ten per cent of the patients surviving the operation developed murmurs of aortic insufficiency. There have been no documented valve failures. Ninety-eight per cent of the survivors have experienced an improvement in their New York Heart Association (N.Y.H.A.) classification.


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B. K. H. Semb and K. V. Hall
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Vascular and Endovascular Surgery, May 1, 1981; 15(3): 193 - 217.
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