The Journal of Thoracic and Cardiovascular Surgery, Vol 71, 262-267, Copyright © 1976 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
Preliminary clinical experience with a new radioisotope-powered cardiac pacemaker
NP Smyth, GJ Magovern, WJ Cushing, JM Keshishian, LC Kelly and M Dixon
A small light-weight nuclear-powered pacer has been developed. The pulse
generator weight 61 Gm. and occupies a volume of 33 sq. cm. It is a
standard R-wave inhibited (VVI) demand pulse generator. The unit has met
all United States and foreign atomic energy commission safety
specifications including mechanical shock, industrial fire, accidental
crush, cremation, impact, and corrosion. Its calculated life is in excess
of 20 years. The unit has been shown to be insensitive to electromagnetic
interference (EMI) over a wide range of commonly encountered sources of
interference. An extensive dog testing program has been carried out and is
continuing. The United States Atomic Energy Commission (AEC) has issued a
license to conduct clinical trials. These began in October, 1974, and a
total of 30 units of 30 units have been implanted so far. An equal number
of chemical battery-powered pulse generators has been implanted in a
control series of 30 patients. Preliminary results have been gratifying.