The Journal of Thoracic and Cardiovascular Surgery, Vol 71, 609-613, Copyright © 1976 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
Plasma ionic calcium levels following injection of chloride, gluconate, and gluceptate salts of calcium
RD White, RS Goldsmith, R Rodriguez, EA Moffitt and JR Pluth
The ionic equivalency of three calcium salts was tested in 15 patients
undergoing cardiac surgery with extracorporeal circulation. Of the three
salts tested (chloride, gluconate, gluceptate), only calcium chloride
showed a reproducible and highly significant relationship between the
increase in total calcium and the increase in ionic calcium. It is
suggested that extracorporeal circulation may be one clinical situation in
which use of a calcium electrode may be of major value. The marked
distortion of plasma proteins and pH, the addition of large amounts of
citrate, and the differences between various calcium salts indicate that it
is probably not possible to predict ionic calcium with assurance and that
direct measurement may be necessary for optimal therapy.