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The Journal of Thoracic and Cardiovascular Surgery, Vol 71, 800-806, Copyright © 1976 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Methylprednisolone. Pharmacologic doses in shock lung syndrome

A Sladen

Patients with shock lung syndrome were identified as those who developed acute respiratory failure after a profound episode of hypotension secondary to hemorrhagic, gram-negative, or endotoxic shock. In this study, each of the 10 patients with shock lung syndrome received methylprednisolone sodium succinate, 30 mg. per kilogram, intravenously every 6 hours for 48 hours. In addition, all patients were supported with mechanical ventilation, with or without positive end-expiratory pressure (PEEP). Arterial oxygenation improved markedly, and pulmonary edema resolved in all patients. Nine were discharged from the hospital and one died subsequently of disseminated intravascular coagulation. This study demonstrated a significant improvement in mortality rate with repeated pharmacologic doses of methylprednisolone compared to previously reported mortality rates of 60 to 90 per cent in patients with shock lung syndrome treated without repeated pharmacologic doses of steroid therapy.


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J Cranshaw, M J D Griffiths, and T W Evans
The pulmonary physician in critical care c 9: Non-ventilatory strategies in ARDS
Thorax, September 1, 2002; 57(9): 823 - 829.
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Copyright © 1976 by The American Association for Thoracic Surgery.