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The Journal of Thoracic and Cardiovascular Surgery, Vol 73, 630-636, Copyright © 1977 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

The behavior of infected arterial prostheses of expanded polytetrafluoroethylene (Gore-Tex)

JP Weiss, FV Lorenzo, CD Campbell, RL Myerowitz and MW Webster

In 11 dogs the bacteriologic and morphologic reaction of arterial prostheses made of expanded polytetrafluoroethylene (Gore-Tex) to an induced Staphylococcus aureus septicemia at time of graft implantation was evaluated and compared to that observed with Dacron grafts in 10 dogs. Graft infection developed in all dogs, manifested by positive blood and graft cultures. Grafts, however, could be clearly classified as either histologically infected or uninfected with a marked difference in the pattern of positive blood cultures. Histologically uninfected grafts in general demonstrated the tissue ingrowth and neointima formation which characterize Gore-Tex despite positive graft culture. The appearance of overt histologic infection was correlated with failure of a neointima to develop. Gore-Tex did not loose its structural integrity despite frank injection. The use of the Gore-Tex in the face of overt infection cannot be supported.

This article has been cited by other articles:

				N. Chakfe, R. Guidoin, M. Marois, P.-E. Roy, Y. Douville, P. Roy, M. Batt, and C. Gosselin A Pathological Study of Arterial Prostheses Surgically Excised after Overt Clinical Infection J Biomater Appl, January 1, 1991; 5(3): 227 - 246. [Abstract] [PDF]

				P. J. Wolfson, M. Haimov, R. Slifkin, and A. Kaynan Pseudoaneurysm Formation in a Gore-Tex Graft Used for Hemodialysis Vascular and Endovascular Surgery, January 1, 1981; 15(1): 35 - 39. [Abstract] [PDF]