The Journal of Thoracic and Cardiovascular Surgery, Vol 75, 585-594, Copyright © 1978 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
Transbronchial mucus transfer of bronchogenic carcinoma
SM Cattaneo, RE Zipf, OE Johnson and LS Everhart
The metastatic transfer of cells from a primary bronchogenic carcinoma to
other portions of the lung as a result of mucus embolization and
inoculation has been demonstrated. Histologic observations indicate tumor
implantation and survival in peripheral bronchioles. In these regions
mucosal dysplasia and carcinoma-in-situ changes which characteristically
accompany a primary lesion are notably absent. Morphologic changes
associated with acute bronchitis and focally denuded bronchial mucosa may
be implicated.