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The Journal of Thoracic and Cardiovascular Surgery, Vol 75, 877-885, Copyright © 1978 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Myocardial protection during ischemic cardiac arrest. The importance of magnesium in cardioplegic infusates

DJ Hearse, DA Stewart and MV Braimbridge

The increasing use of coronary infusates for the protection of the human heart drug ischemic cardiac arrest has placed great emphasis on the need for a rational and safe formulation of any infusion solution. Using a rat heart model of cardiopulmonary bypass and ischemic cardiac arrest, we have found magnesium to be a highly effective component of protective infusates which can be additive to hypothermia and other protective agents. However, the concentration of magnesium bears a complex relationship to the degree of protection, a fact which stresses the need for the establishment of the correct concentration for optimal protection.




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Copyright © 1978 by The American Association for Thoracic Surgery.