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The Journal of Thoracic and Cardiovascular Surgery, Vol 77, 896-899, Copyright © 1979 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association


ARTICLES

Effects of methylprednisolone in cardioplegic solution during coronary bypass grafting

MM Kirsh, DM Behrendt and KE Jochim

The effects of adding 500 mg. of methylprednisolone to each liter of cardioplegic solution were studied in patients undergoing coronary artery bypass grafts. Patients were randomly assigned to control (12 patients) or steroid-treated groups (10 patients). The cardioplegic solution was identical in the two groups except for the added methylprednisolone. Contractile element velocity (VCE and left ventricular end-diastolic pressure (LVEDP) were recorded immediately before and after perfusion in the operating room. There were no differences between the two groups with respect to these two variables or the postoperative courses. Thus this study fails to demonstrate a beneficial effect of methylprednisolone when added to cardioplegic solutions.





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Copyright © 1979 by The American Association for Thoracic Surgery.