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The Journal of Thoracic and Cardiovascular Surgery, Vol 77, 908-913, Copyright © 1979 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Comparative study of prophylactic antibiotics in cardiac surgery. Clindamycin versus cephalothin

FD Pien, NL Michael, R Mamiya, H Takaki, S Slavish, A Bruce and RJ Moreno-Cabral

A randomized, prospective study of the relative effectiveness of clindamycin versus cephalothin was performed in 263 adult patients having cardiac surgery from September, 1977, to August, 1978. There were no statistically significant differences in frequency of postoperative infections in these two antibiotic groups. Wound infection developed in 6.5 percent of the cephalothin group and 3.2 percent of the clindamycin group. Urinary tract infection developed in 5.6 percent of the clindamycin group and 2.1 percent of the cephalothin group. Four bacteremic episodes occurred in the clindamycin-treated patients, and one episode of bacteremia occurred in a cephalothin- treated patient. No cases of endocarditis occurred during the study. Clindamycin deserved consideration as an alternative prophylactic agent to cephalothin for cardiac surgery.




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Copyright © 1979 by The American Association for Thoracic Surgery.