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The Journal of Thoracic and Cardiovascular Surgery, Vol 83, 878-890, Copyright © 1982 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
GB Haasler, PC Rodigas and HM Spotnitz
Because of divergent conclusions in the literature regarding the effects of
temperature on end-diastolic compliance in the canine left ventricle (LV),
pressure-volume relationships at normothermia and hypothermia (28 degrees
C) were studied with two-dimensional ultrasound in nine dogs on
cardiopulmonary bypass (open pericardium) over a range of left ventricular
end-diastolic pressure (LVEDP) from 0 to 22 mm Hg. Three perpendicular
echocardiographic sections were used with Simpson's rule to measure LV
volume and mass at end-diastole for each level of LVEDP. Temperature was
varied between 37 degrees and 28 degrees C by systemic cooling, and heart
rate was allowed to slow spontaneously with temperature reduction. There
was no change in left ventricular end- diastole pressure-volume
(LVEDP-LVEDV) relationships at lower temperature provided that ventricular
relaxation was complete at end- diastole. In addition, serial postmortem
pressure-volume curves carried out by direct saline infusion into sealed
ventricles at 38 degrees and 28 degrees C in three additional dogs
demonstrated no temperature effects on postmortem LV compliance. Postmortem
mass correlated well with echocardiographically determined LV mass, which
showed a significant increase during the period of cardiopulmonary bypass,
correlating with the development of myocardial edema. In summary, there
appears to be no effect of moderate hypothermia on LVEDP-LVEDV
relationships, provided the heart is in true diastasis at end-diastole. In
addition, echocardiographic techniques can be used to study LV mass change
on cardiopulmonary bypass.
ARTICLES
The absence of temperature effects on end-diastolic pressure-volume relations in the canine left ventricle determined by two-dimensional echocardiography
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