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The Journal of Thoracic and Cardiovascular Surgery, Vol 88, 402-410, Copyright © 1984 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
ER Rosenkranz, F Okamoto, GD Buckberg, J Vinten-Johansen, JM Robertson and H Bugyi
Cold blood cardioplegic techniques are limited in their ability to protect
energy-depleted hearts during aortic clamping. This study extends our
previous observations on the benefits of amino acid (L- glutamate)
enrichment of blood cardioplegic solutions as well as the added metabolic
benefits of normothermic induction of cardioplegic arrest to increase the
rate of repair of energy-depleted hearts. The results demonstrate that
L-glutamate enrichment of blood cardioplegic solutions significantly
improves metabolic recovery (greater oxygen consumption, better anaerobic
metabolism) and ventricular performance. Normothermic induction of
glutamate-enriched cardioplegia allowed complete recovery of myocardial
metabolism and function compared to cold blood cardioplegic technique and
may be used as a form of "active resuscitation" of energy-depleted hearts.
ARTICLES
Safety of prolonged aortic clamping with blood cardioplegia. II. Glutamate enrichment in energy-depleted hearts
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