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The Journal of Thoracic and Cardiovascular Surgery, Vol 89, 439-443, Copyright © 1985 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
MF Matangi, JM Neutze, KJ Graham, DG Hill, AR Kerr and BG Barratt-Boyes
After aorta-coronary bypass grafting, 164 consecutive patients were
randomized to receive propranolol 5 mg every 6 hours orally (n = 82) or to
serve as control subjects (n = 82). All patients were receiving beta
blockers preoperatively. There were no significant differences between the
two groups. The incidence of sustained supraventricular (nonsinus)
tachyarrhythmias was 23% in the control group and 9.8% in the treated group
(p = 0.02). The incidence of ventricular arrhythmias was 15% in the control
group and 2.4% in the treated group (p = 0.005). The overall difference in
clinically important arrhythmias was 38% in the control group and 12.2% in
the treated group (p = 0.0002). We conclude that low-dose oral propranolol
in patients who were receiving beta blockers preoperatively is effective in
reducing the incidence of clinically important arrhythmias occurring after
aorta-coronary bypass grafting.
ARTICLES
Arrhythmia prophylaxis after aorta-coronary bypass. The effect of minidose propranolol
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