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The Journal of Thoracic and Cardiovascular Surgery, Vol 92, 361-384, Copyright © 1986 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
JM Quaegebeur, J Rohmer, J Ottenkamp, T Buis, JW Kirklin, EH Blackstone and AG Brom
Sixty-six patients (23 neonates with transposition of the great arteries
and intact ventricular septum, 33 infants and children with transposition
and a large ventricular septal defect, and 10 with double- outlet right
ventricle with a subpulmonary ventricular septal defect have received an
arterial switch repair since 1977. Eight (one with transposition and intact
ventricular septum, six with transposition and ventricular septal defect,
and one with double-outlet right ventricle with subpulmonary ventricular
septal defect) died in the hospital. All other patients have had follow-up
as of June, 1985. Including the hospital deaths, the 11 month actuarial
survival rate for the entire group was 81%, and no deaths have occurred
among the 33 patients alive at that time and traced as long as 8 years. The
hazard function for death has only a single early phase, and its 70%
confidence limits overlap the hazard function of a matched general
population by 12 months after the operation. Incremental risk factors for
death included low birth weight (but not weight or age at operation),
transposition of the great arteries with large ventricular septal defect,
double-outlet right ventricle with subpulmonary ventricular septal defect,
and presence of a patent ductus arteriosus. Coronary artery morphology and
position of the great arteries were not risk factors. Long aortic cross-
clamp time was possibly (p = 0.11) a risk factor. Early date of operation
was a risk factor (p = 0.004); thus, predicted 1 year survival rate,
including hospital deaths, after the arterial switch operation in 1985 is
99.9% (70% confidence limits 99.0%-100%) for neonates with transposition
and intact ventricular septum and 99.7% (98.4%-99.9%) for those with
transposition and a large ventricular septal defect or double-outlet right
ventricle. The late functional status was excellent, and the rhythm was
sinus in 96% of the 55 surviving patients. A formal comparison with the
results of the atrial switch repair indicates that the arterial switch
repair is superior.
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The arterial switch operation. An eight-year experience
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