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The Journal of Thoracic and Cardiovascular Surgery, Vol 93, 860-866, Copyright © 1987 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
E Fosse, TE Mollnes and B Ingvaldsen
Plasma concentrations of the complement products C3dg and the terminal
complement complex, as well as the number of granulocytes
(polymorphonuclear neutrophils), were assessed in patients undergoing
aorta-coronary bypass with extracorporeal circulation, abdominal
aneurysmectomy with implantation of an aortic graft, or thoracotomy without
the introduction of synthetic material into the circulation. The
concentration of terminal complement complex increased significantly only
in the group undergoing extracorporeal circulation, with a corresponding
drop in the number of granulocytes. In contrast, the C3dg concentration
increased during both extracorporeal circulation and abdominal
aneurysmectomy, which indicates that other factors than extracorporeal
circulation may affect C3 activation during major operations. In the
thoracotomy group, where the most pronounced increase in granulocytes was
found, no complement activation was recorded. It is concluded that
extracorporeal circulation activates the terminal pathway of complement and
that assays detecting activation of both the initial and the terminal parts
should be included when the pathophysiology of complement is examined
during major operations and extracorporeal circulation.
ARTICLES
Complement activation during major operations with or without cardiopulmonary bypass
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