HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Frist, W. H. Articles by Shumway, N. E. Search for Related Content PubMed PubMed Citation Articles by Frist, W. H. Articles by Shumway, N. E.

The Journal of Thoracic and Cardiovascular Surgery, Vol 94, 685-693, Copyright © 1987 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Long-term hemodynamic results after cardiac transplantation

WH Frist, EB Stinson, PE Oyer, JC Baldwin and NE Shumway
Department of Cardiovascular Surgery, Stanford University Medical Center, Calif. 94305.

Although survival after cardiac transplantation has improved since the introduction of cyclosporine to clinical practice in 1980, the long- term hemodynamic results of transplantation in cyclosporine-treated recipients has not been reported. Annual cardiac catheterization data for 109 cyclosporine-treated recipients were analyzed and compared to those of a nonconcurrent group of 65 recipients treated with azathioprine and corticosteroids. Recipient age, donor age, sex, and human leukocyte antigen mismatch were comparable for the two groups. Satisfactory left ventricular function of the cyclosporine-treated heart was characterized on the first annual study by a normal ejection fraction (60% +/- 10%), cardiac index (3.0 +/- 0.8 L/min/m2) and stroke work index (53 +/- 15 gm-m/m2) associated with moderately increased left ventricular end-diastolic pressures (12 +/- 6 mm Hg) and significantly increased mean aortic pressures (116 +/- 8 mm Hg). With the exception of aortic diastolic pressure, which tended to increase with time, the mean values of each variable analyzed did not change significantly over the period of study. In comparison to the azathioprine group, the cyclosporine cohort displayed higher aortic, left ventricular end-diastolic, and pulmonary artery pressures and produced more stroke work at each annual study. Analysis of the azathioprine group over extended (8 year) follow-up suggested excellent preservation of graft function. In summary, the long-term hemodynamic function of the transplanted heart treated with cyclosporine was satisfactory, demonstrated no deterioration over 5 year follow-up, but manifested substantially greater hypertension than hearts from the pre- cyclosporine era.

This article has been cited by other articles:

				R. John, H. A. Rajasinghe, S. Itescu, S. Suratwalla, K. Lietz, A. D. Weinberg, A. Kocher, D. M. Mancini, R. E. Drusin, M. C. Oz, et al. Factors affecting long-term survival (>10 years) after cardiac transplantation in the cyclosporine era J. Am. Coll. Cardiol., January 1, 2001; 37(1): 189 - 194. [Abstract] [Full Text] [PDF]

				S Fraund, K Pethig, U Franke, T Wahlers, W Harringer, J Cremer, H-G Fieguth, P Oppelt, and A Haverich Ten year survival after heart transplantation: palliative procedure or successful long term treatment? Heart, July 1, 1999; 82(1): 47 - 51. [Abstract] [Full Text] [PDF]

				M. J. Carvalho, A. H. van den Meiracker, F. Boomsma, J. Freitas, A. J. Man in `t Veld, O. Costa, and A. F. de Freitas Role of Sympathetic Nervous System in Cyclosporine-Induced Rise in Blood Pressure Hypertension, July 1, 1999; 34(1): 102 - 106. [Abstract] [Full Text] [PDF]

				R. Hetzer, W. Albert, M. Hummel, M. Pasic, M. Loebe, H. Warnecke, A. Haverich, and H. G. Borst Status of Patients Presently Living 9 to 13 Years After Orthotopic Heart Transplantation Ann. Thorac. Surg., December 1, 1997; 64(6): 1661 - 1668. [Abstract] [Full Text]

				R. G. Leyh, A. W. Jahnke, E. G. Kraatz, and H.-H. Sievers Cardiovascular Dynamics and Dimensions After Bicaval and Standard Cardiac Transplantation Ann. Thorac. Surg., June 1, 1995; 59(6): 1495 - 1500. [Abstract] [Full Text]

				W. M. DeCampli, H. Luikart, S. Hunt, and E. B. Stinson Characteristics of patients surviving more than ten years aftercardiac transplantation J. Thorac. Cardiovasc. Surg., June 1, 1995; 109(6): 1103 - 1115. [Abstract] [Full Text]

				U. Livi, U. Bortolotti, G. B. Luciani, G. M. Boffa, A. Milano, G. Thiene, D. Casarotto, and S. b. N. E. Shumway Donor shortage in heart transplantationIs extension of donor age limits justified? J. Thorac. Cardiovasc. Surg., May 1, 1994; 107(5): 1346 - 1355. [Abstract] [Full Text]