|
|
||||||||
The Journal of Thoracic and Cardiovascular Surgery, Vol 96, 440-447, Copyright © 1988 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
T Naruke, T Goya, R Tsuchiya and K Suemasu
A new TNM staging system was proposed and the previous system has been
revised recently. To evaluate the new TNM staging system for lung cancer,
we analyzed records of 1737 patients who underwent pulmonary resection at
the National Cancer Center Hospital, Tokyo. With regard to clinical stages,
three patients had occult carcinoma; 821 patients had stage I disease; 248
patients, stage II; 465 patients, stage IIIA; 82 patients, stage IIIB; and
118 patients, stage IV. The 5-year survival rates for the respective stages
were 50.1% for stage I, 31.2% for stage II, 20.2% for stage IIIA, 5.1% for
stage IIIB, and 7.9% for stage IV. In terms of postoperative stages, four
patients were classified in stage 0, 536 in stage I, 221 in stage II, 559
in stage IIIA, 159 in stage IIIB, and 258 in stage IV. The 5-year survival
rates were as follows: stage I, 65.0%; stage II, 42.9%; stage IIIA, 22.2%;
stage IIIB, 5.6%; and stage IV, 7.5%. In both the clinical stage and the
postoperative stage, there were significant prognostic differences between
stage I and stage II, stage II and stage IIIA, and stage IIIA and stage
IIIB, but there was no significant difference in 5-year survival rates
between stage IIIB and stage IV.
ARTICLES
Prognosis and survival in resected lung carcinoma based on the new international staging system [published erratum appears in J Thorac Cardiovasc Surg 1989 Mar;97(3):350]
Department of Surgery, National Cancer Center Hospital, Tokyo, Japan.
This article has been cited by other articles:
![]() |
F. M.A. Melfi, M. Lucchi, F. Davini, A. Viti, G. Fontanini, L. Boldrini, G. Boni, and A. Mussi Intraoperative sentinel lymph node mapping in stage I non-small cell lung cancer: detection of micrometastases by polymerase chain reaction. Eur. J. Cardiothorac. Surg., July 1, 2008; 34(1): 181 - 186. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Leschber, D. Sperling, W. Klemm, and J. Merk Does video-mediastinoscopy improve the results of conventional mediastinoscopy? Eur. J. Cardiothorac. Surg., February 1, 2008; 33(2): 289 - 293. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. K. Lau, P. C. Boutros, M. Pintilie, F. H. Blackhall, C.-Q. Zhu, D. Strumpf, M. R. Johnston, G. Darling, S. Keshavjee, T. K. Waddell, et al. Three-Gene Prognostic Classifier for Early-Stage Non Small-Cell Lung Cancer J. Clin. Oncol., December 10, 2007; 25(35): 5562 - 5569. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Jeremic Low Incidence of Isolated Nodal Failures After Involved-Field Radiation Therapy for Non Small-Cell Lung Cancer: Blinded by the Light? J. Clin. Oncol., December 10, 2007; 25(35): 5543 - 5545. [Full Text] [PDF] |
||||
![]() |
O. Rena, L. Carsana, S. Cristina, E. Papalia, F. Massera, L. Errico, C. Bozzola, and C. Casadio Lymph node isolated tumor cells and micrometastases in pathological stage I non-small cell lung cancer: prognostic significance Eur. J. Cardiothorac. Surg., December 1, 2007; 32(6): 863 - 867. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Y. Chang, S. J. Mentzer, Y. L. Colson, P. A. Linden, M. T. Jaklitsch, S. R. Lipsitz, and D. J. Sugarbaker Factors predicting poor survival after resection of stage IA non-small cell lung cancer. J. Thorac. Cardiovasc. Surg., October 1, 2007; 134(4): 850 - 856. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Rao, R. A. Sayeed, S. Tomaszek, S. Fischer, S. Keshavjee, and G. E. Darling Prognostic Factors in Resected Satellite Nodule T4 Non-Small Cell Lung Cancer Ann. Thorac. Surg., September 1, 2007; 84(3): 934 - 939. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. A. Whitson, S. S. Groth, and M. A. Maddaus Surgical Assessment and Intraoperative Management of Mediastinal Lymph Nodes in Non-Small Cell Lung Cancer Ann. Thorac. Surg., September 1, 2007; 84(3): 1059 - 1065. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Tsuchiya, S. Hashizume, S. Akamine, M. Muraoka, S. Honda, K. Tsuji, S. Urabe, T. Hayashi, N. Yamasaki, and T. Nagayasu Upstaging by Vessel Invasion Improves the Pathology Staging System of Non-Small Cell Lung Cancer Chest, July 1, 2007; 132(1): 170 - 177. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Witte, M. Wolf, M. Huertgen, and H. Toomes Video-Assisted Mediastinoscopic Surgery: Clinical Feasibility and Accuracy of Mediastinal Lymph Node Staging Ann. Thorac. Surg., November 1, 2006; 82(5): 1821 - 1827. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Timmerman, R. McGarry, C. Yiannoutsos, L. Papiez, K. Tudor, J. DeLuca, M. Ewing, R. Abdulrahman, C. DesRosiers, M. Williams, et al. Excessive Toxicity When Treating Central Tumors in a Phase II Study of Stereotactic Body Radiation Therapy for Medically Inoperable Early-Stage Lung Cancer J. Clin. Oncol., October 20, 2006; 24(30): 4833 - 4839. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Raponi, Y. Zhang, J. Yu, G. Chen, G. Lee, J. M.G. Taylor, J. MacDonald, D. Thomas, C. Moskaluk, Y. Wang, et al. Gene expression signatures for predicting prognosis of squamous cell and adenocarcinomas of the lung. Cancer Res., August 1, 2006; 66(15): 7466 - 7472. [Abstract] [Full Text] [PDF] |
||||
![]() |
M.-F. Tsai, C.-C. Wang, G.-C. Chang, C.-Y. Chen, H.-Y. Chen, C.-L. Cheng, Y.-P. Yang, C.-Y. Wu, F.-Y. Shih, C.-C. Liu, et al. A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma. J Natl Cancer Inst, June 21, 2006; 98(12): 825 - 838. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Guo, Y. Ma, R. Ward, V. Castranova, X. Shi, and Y. Qian Constructing Molecular Classifiers for the Accurate Prognosis of Lung Adenocarcinoma. Clin. Cancer Res., June 1, 2006; 12(11): 3344 - 3354. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. M. Oken, P. M. Marcus, P. Hu, T. M. Beck, W. Hocking, P. A. Kvale, J. Cordes, T. L. Riley, S. D. Winslow, S. Peace, et al. Baseline Chest Radiograph for Lung Cancer Detection in the Randomized Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial J Natl Cancer Inst, December 21, 2005; 97(24): 1832 - 1839. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Nakagawa, N. Okumura, K. Miyoshi, T. Matsuoka, and K. Kameyama Prognostic factors in patients with ipsilateral pulmonary metastasis from non-small cell lung cancer Eur. J. Cardiothorac. Surg., October 1, 2005; 28(4): 635 - 639. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Jeremic, B. Milicic, L. Acimovic, and S. Milisavljevic Concurrent Hyperfractionated Radiotherapy and Low-Dose Daily Carboplatin/Paclitaxel in Patients With Early-Stage (I/II) Non-Small-Cell Lung Cancer: Long-Term Results of a Phase II Study J. Clin. Oncol., October 1, 2005; 23(28): 6873 - 6880. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Donati, L. Boldrini, M. Dell'Omodarme, M. C. Prati, P. Faviana, T. Camacci, M. Lucchi, A. Mussi, M. Santoro, F. Basolo, et al. Osteopontin Expression and Prognostic Significance in Non-Small Cell Lung Cancer Clin. Cancer Res., September 15, 2005; 11(18): 6459 - 6465. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Xi, J. Lyons-Weiler, M. C. Coello, X. Huang, W. E. Gooding, J. D. Luketich, and T. E. Godfrey Prediction of Lymph Node Metastasis by Analysis of Gene Expression Profiles in Primary Lung Adenocarcinomas Clin. Cancer Res., June 1, 2005; 11(11): 4128 - 4135. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Ishikawa, T. Nakagawa, R. Miyahara, Y. Kawano, K. Takenaka, K. Yanagihara, Y. Otake, H. Katakura, H. Wada, and F. Tanaka Expression of MDA-7/IL-24 and Its Clinical Significance in Resected Non-Small Cell Lung Cancer Clin. Cancer Res., February 1, 2005; 11(3): 1198 - 1202. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Chen, K. Takenaka, E. Ogawa, K. Yanagihara, Y. Otake, H. Wada, and F. Tanaka Flt-4-Positive Endothelial Cell Density and Its Clinical Significance in Non-Small Cell Lung Cancer Clin. Cancer Res., December 15, 2004; 10(24): 8548 - 8553. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Lorent, P. De Leyn, Y. Lievens, E. Verbeken, K. Nackaerts, C. Dooms, D. Van Raemdonck, B. Anrys, J. Vansteenkiste, and The Leuven Lung Cancer Group Long-term survival of surgically staged IIIA-N2 non-small-cell lung cancer treated with surgical combined modality approach: analysis of a 7-year prospective experience Ann. Onc., November 1, 2004; 15(11): 1645 - 1653. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Ikeda, J. Maeda, K. Yashima, M. Tsuboi, H. Kato, S. Akada, and S. Okada A clinicopathological study of resected adenocarcinoma 2 cm or less in diameter Ann. Thorac. Surg., September 1, 2004; 78(3): 1011 - 1016. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Roviaro, F. Varoli, C. Vergani, O. Nucca, M. Maciocco, and F. Grignani Long-term Survival After Videothoracoscopic Lobectomy for Stage I Lung Cancer Chest, September 1, 2004; 126(3): 725 - 732. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Halter, A. K. Buck, H. Schirrmeister, I. Wurziger, F. Liewald, G. Glatting, B. Neumaier, L. Sunder-Plassmann, S. N. Reske, and M. Hetzel [18F] 3-deoxy-3'-fluorothymidine positron emission tomography: Alternative or diagnostic adjunct to 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography in the workup of suspicious central focal lesions? J. Thorac. Cardiovasc. Surg., April 1, 2004; 127(4): 1093 - 1099. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Inoue, N. Sawabata, S.-i. Takeda, M. Ohta, Y. Ohno, and H. Maeda Results of surgical intervention for p-stage IIIA (N2) non-small cell lung cancer: Acceptable prognosis predicted by complete resection in patients with single N2 disease with primary tumor in the upper lobe J. Thorac. Cardiovasc. Surg., April 1, 2004; 127(4): 1100 - 1106. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. G. Byrne, M. Leacche, A. K. Agnihotri, S. Paul, R. Bueno, D. J. Mathisen, and D. J. Sugarbaker The Use of Cardiopulmonary Bypass During Resection of Locally Advanced Thoracic Malignancies: A 10-Year Two-Center Experience Chest, April 1, 2004; 125(4): 1581 - 1586. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Sayar, A. Turna, A. Kilicgun, O. Solak, N. Urer, and A. Gurses Prognostic significance of surgical-pathologic multiple-station N1 disease in non-small cell carcinoma of the lung Eur. J. Cardiothorac. Surg., March 1, 2004; 25(3): 434 - 438. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. V. Brock, M. P. Kim, C. M. Hooker, A. J. Alberg, M. M. Jordan, C. M. Roig, L. Xu, and S. C. Yang Pulmonary resection in octogenarians with stage I nonsmall cell lung cancer: a 22-year experience Ann. Thorac. Surg., January 1, 2004; 77(1): 271 - 277. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Chen, T. G Gharib, H. Wang, C.-C. Huang, R. Kuick, D. G. Thomas, K. A. Shedden, D. E. Misek, J. M. G. Taylor, T. J. Giordano, et al. Protein profiles associated with survival in lung adenocarcinoma PNAS, November 11, 2003; 100(23): 13537 - 13542. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Timmerman, L. Papiez, R. McGarry, L. Likes, C. DesRosiers, S. Frost, and M. Williams Extracranial Stereotactic Radioablation: Results of a Phase I Study in Medically Inoperable Stage I Non-small Cell Lung Cancer Chest, November 1, 2003; 124(5): 1946 - 1955. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Leschber, G. Holinka, and A. Linder Video-assisted mediastinoscopic lymphadenectomy (VAMLA) - a method for systematic mediastinal lymphnode dissection Eur. J. Cardiothorac. Surg., August 1, 2003; 24(2): 192 - 195. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Marra, L. Hillejan, G. Zaboura, T. Fujimoto, D. Greschuchna, and G. Stamatis Pathologic N1 non-small cell lung cancer: Correlation between pattern of lymphatic spread and prognosis J. Thorac. Cardiovasc. Surg., March 1, 2003; 125(3): 543 - 553. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. M.A. Melfi, A. Chella, G. F. Menconi, F. Givigliano, G. Boni, G. Mariani, P. Sbragia, and C. A. Angeletti Intraoperative radioguided sentinel lymph node biopsy in non-small cell lung cancer Eur. J. Cardiothorac. Surg., February 1, 2003; 23(2): 214 - 220. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Nagai, R. Tsuchiya, T. Mori, H. Tada, Y. Ichinose, T. Koike, and H. Kato A randomized trial comparing induction chemotherapy followed by surgery with surgery alone for patients with stage IIIA N2 non-small cell lung cancer (JCOG 9209) J. Thorac. Cardiovasc. Surg., February 1, 2003; 125(2): 254 - 260. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Patane, A. Verzini, E. Zingarelli, and M. di Summa Simultaneous operation for cardiac disease and lung cancer Interactive CardioVascular and Thoracic Surgery, December 1, 2002; 1(2): 69 - 71. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. T. Winer-Muram, S. G. Jennings, R. D. Tarver, A. M. Aisen, M. Tann, D. J. Conces, and C. A. Meyer Volumetric Growth Rate of Stage I Lung Cancer prior to Treatment: Serial CT Scanning Radiology, June 1, 2002; 223(3): 798 - 805. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Sok, M. Sentjurc, M. Schara, J. Stare, and T. Rott Cell membrane fluidity and prognosis of lung cancer Ann. Thorac. Surg., May 1, 2002; 73(5): 1567 - 1571. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Sawabata, A. Matsumura, A. Motohiro, Y. Osaka, K. Gennga, S. Fukai, and T. Mori Malignant minor pleural effusion detected on thoracotomy for patients with non-small cell lung cancer: is tumor resection beneficial for prognosis? Ann. Thorac. Surg., February 1, 2002; 73(2): 412 - 415. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Deslauriers Current surgical treatment of nonsmall cell lung cancer 2001 Eur. Respir. J., February 1, 2002; 19(35_suppl): 61S - 70s. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. F. Esnaola, S. N. Lazarides, S. J. Mentzer, and K. M. Kuntz Outcomes and Cost-Effectiveness of Alternative Staging Strategies for Non-Small-Cell Lung Cancer J. Clin. Oncol., January 1, 2002; 20(1): 263 - 273. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Higashi, Y. Ueda, Y. Arisaka, T. Sakuma, Y. Nambu, M. Oguchi, H. Seki, S. Taki, H. Tonami, and I. Yamamoto 18F-FDG Uptake as a Biologic Prognostic Factor for Recurrence in Patients with Surgically Resected Non-Small Cell Lung Cancer J. Nucl. Med., January 1, 2002; 43(1): 39 - 45. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Usadel, J. Brabender, K. D. Danenberg, C. Jeronimo, S. Harden, J. Engles, P. V. Danenberg, S. Yang, and D. Sidransky Quantitative Adenomatous Polyposis Coli Promoter Methylation Analysis in Tumor Tissue, Serum, and Plasma DNA of Patients with Lung Cancer Cancer Res., January 1, 2002; 62(2): 371 - 375. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Bernard, O. Bouchot, O. Hagry, and J. P. Favre Risk analysis and long-term survival in patients undergoing resection of T4 lung cancer Eur. J. Cardiothorac. Surg., August 1, 2001; 20(2): 344 - 349. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Naruke, R. Tsuchiya, H. Kondo, and H. Asamura Prognosis and survival after resection for bronchogenic carcinoma based on the 1997 TNM-staging classification: the Japanese experience Ann. Thorac. Surg., June 1, 2001; 71(6): 1759 - 1764. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. Takanami, K. Takeuchi, and M. Giga The prognostic value of natural killer cell infiltration in resected pulmonary adenocarcinoma J. Thorac. Cardiovasc. Surg., June 1, 2001; 121(6): 1058 - 1063. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. R. Khuri, H. Wu, J. J. Lee, B. L. Kemp, R. Lotan, S. M. Lippman, L. Feng, W. K. Hong, and X.-C. Xu Cyclooxygenase-2 Overexpression Is a Marker of Poor Prognosis in Stage I Non-Small Cell Lung Cancer Clin. Cancer Res., April 1, 2001; 7(4): 861 - 867. [Abstract] [Full Text] |
||||
![]() |
B. Jeremic, Y. Shibamoto, L. Acimovic, N. Nikolic, A. Dagovic, J. Aleksandrovic, and G. Radosavljevic-Asic Second Cancers Occurring in Patients With Early Stage Non-Small-Cell Lung Cancer Treated With Chest Radiation Therapy Alone J. Clin. Oncol., February 15, 2001; 19(4): 1056 - 1063. [Abstract] [Full Text] [PDF] |
||||
![]() |
Investigating extrathoracic metastatic disease in patients with apparently operable lung cancer Ann. Thorac. Surg., February 1, 2001; 71(2): 425 - 433. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Bueno, W. G. Richards, S. J. Swanson, M. T. Jaklitsch, J. M. Lukanich, S. J. Mentzer, and D. J. Sugarbaker Nodal stage after induction therapy for stage IIIA lung cancer determines patient survival Ann. Thorac. Surg., December 1, 2000; 70(6): 1826 - 1831. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Asamura, K. Suzuki, H. Kondo, and R. Tsuchiya Where is the boundary between N1 and N2 stations in lung cancer? Ann. Thorac. Surg., December 1, 2000; 70(6): 1839 - 1846. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Chapelier, E. Fadel, P. Macchiarini, B. Lenot, F. Le Roy Ladurie, J. Cerrina, and P. Dartevelle Factors affecting long-term survival after en-bloc resection of lung cancer invading the chest wall Eur. J. Cardiothorac. Surg., November 1, 2000; 18(5): 513 - 518. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Hashimoto, Y. Kobayashi, Y. Ishikawa, S. Tsuchiya, S. Okumura, K. Nakagawa, Y. Tokuchi, M. Hayashi, K. Nishida, S.-i. Hayashi, et al. Prognostic Value of Genetically Diagnosed Lymph Node Micrometastasis in Non-Small Cell Lung Carcinoma Cases Cancer Res., November 1, 2000; 60(22): 6472 - 6478. [Abstract] [Full Text] |
||||
![]() |
K. Yokoi, R. Tsuchiya, T. Mori, K. Nagai, T. Furukawa, S. Fujimura, K. Nakagawa, and Y. Ichinose Results of surgical treatment of lung cancer involving the diaphragm J. Thorac. Cardiovasc. Surg., October 1, 2000; 120(4): 799 - 805. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. R. Khuri, R. Lotan, B. L. Kemp, S. M. Lippman, H. Wu, L. Feng, J. J. Lee, C. S. Cooksley, B. Parr, E. Chang, et al. Retinoic Acid Receptor-Beta as a Prognostic Indicator in Stage I Non-Small-Cell Lung Cancer J. Clin. Oncol., August 15, 2000; 18(15): 2798 - 2804. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. J. Liptay, G. A. Masters, D. J. Winchester, B. L. Edelman, B. J. Garrido, T. R. Hirschtritt, R. M. Perlman, and W. A. Fry Intraoperative radioisotope sentinel lymph node mapping in non-small cell lung cancer Ann. Thorac. Surg., August 1, 2000; 70(2): 384 - 389. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Jassem, J. Skokowski, R. Dziadziuszko, E. Jassem, A. Szymanowska, W. Rzyman, and A. Roszkiewicz RESULTS OF SURGICAL TREATMENT OF NON-SMALL CELL LUNG CANCER: VALIDATION OF THE NEW POSTOPERATIVE PATHOLOGIC TNM CLASSIFICATION J. Thorac. Cardiovasc. Surg., June 1, 2000; 119(6): 1141 - 1146. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Ferretti, G. Curigliano, U. Pastorino, A. Cittadini, G. Flamini, M. G. Calabrò, Tommaso De Pas, L. Orlando, M. Mandalà, M. Colleoni, et al. Detection by Denaturant Gradient Gel Electrophoresis of Tumor-specific Mutations in Biopsies and Relative Bronchoalveolar Lavage Fluid from Resectable Non-Small Cell Lung Cancer Clin. Cancer Res., June 1, 2000; 6(6): 2393 - 2400. [Abstract] [Full Text] |
||||
![]() |
T. Niki, S. Iba, M. Tokunou, T. Yamada, Y. Matsuno, and S. Hirohashi Expre |