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The Journal of Thoracic and Cardiovascular Surgery, Vol 96, 746-755, Copyright © 1988 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
RA Jonas, G Ziemer, L Britton and LC Armiger
There is a paucity of clinical and experimental data regarding the fate of
cryopreserved valve aortic homografts. Fifteen lambs (mean age 4 months)
underwent insertion of a valved aortic homograft between the right
ventricle and pulmonary artery. In eight animals, the homografts were
treated with antibiotics for 48 hours followed by up to 4 days of 4 degrees
C storage (group A). In the other seven animals, the homografts were
treated with antibiotics and cryopreserved at -196 degrees C (group B). The
12 long-term survivors were catheterized at 6 weeks and 4 months after
implantation, at which time three animals from each group were killed. The
remaining six animals were catheterized and killed at 9 months. There was
no significant difference in transconduit gradient (p = 0.67) or resistance
indexed to weight (p = 0.81) between groups A and B. The mean increase in
transconduit gradient for both groups between catheterization at 6 weeks
and 4 months was 73%, and weight increased by 51%. Histologic analysis
focusing particularly on valve leaflet architecture and changes in the
aortic wall revealed greater differences between individual animals and
according to duration of implantation than differences between groups A and
B. However, focal intracuspal thrombus of unknown significance was seen
only in animals from group B. Although conduit valve leaflets generally
remained free of calcification, calcification was prominent within the
conduit wall of all animals. In conclusion, cryopreservation does not
appear to adversely affect leaflet integrity and conduit function in this
accelerated animal model relative to fresh homografts. This is in contrast
to past clinical experience with homografts treated by freeze- drying and
irradiation.
ARTICLES
Cryopreserved and fresh antibiotic-sterilized valved aortic homograft conduits in a long-term sheep model. Hemodynamic, angiographic, and histologic comparisons
Department of Cardiac Surgery, Children's Hospital, Boston, Mass. 02115.
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  E. Hickey, S. M. Langley, O. Allemby-Smith, S. A. Livesey, and J. L. Monro Subcoronary Allograft Aortic Valve Replacement: Parametric Risk-Hazard Outcome Analysis to a Minimum of 20 Years Ann. Thorac. Surg., November 1, 2007; 84(5): 1564 - 1570. [Abstract] [Full Text] [PDF]
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 R. N. Mitchell, R. A. Jonas, and F. J. Schoen Pathology Of Explanted Cryopreserved Allograft Heart Valves: Comparison With Aortic Valves From Orthotopic Heart Transplants J. Thorac. Cardiovasc. Surg., January 1, 1998; 115(1): 118 - 127. [Abstract] [Full Text] [PDF]
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J. E. Molina, J. E. Edwards, R. W. Bianco, R. W. Clack, G. Lang, and J. R. Molina COMPOSITE AND PLAIN TUBULAR SYNTHETIC GRAFT CONDUITS IN RIGHT VENTRICLE-PULMONARY ARTERY POSITION: FATE IN GROWING LAMBS J. Thorac. Cardiovasc. Surg., August 1, 1995; 110(2): 427 - 435. [Abstract] [Full Text]
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M. A. Salim, T. G. DiSessa, B. S. Alpert, K. L. Arheart, W. M. Novick, and D. C. Watson Jr The Fate of Homograft Conduits in Children With Congenital Heart Disease: An Angiographic Study Ann. Thorac. Surg., January 1, 1995; 59(1): 67 - 73. [Abstract] [Full Text]
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 G.W. Christie Anatomy of aortic heart valve leaflets: the influence of glutaraldehyde fixation on function Eur. J. Cardiothorac. Surg., January 1, 1992; 6(suppl_1): S25 - S33. [Abstract] [PDF]
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