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The Journal of Thoracic and Cardiovascular Surgery, Vol 98, 783-787, Copyright © 1989 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
C Saldanha and DJ Hearse
Using the isolated, Langendorff-perfused rat heart (n = 8 per group), we
have studied the effects of 5-hydroxytryptamine and papaverine on coronary
flow before and after a 30-minute infusion of hypothermic (20 degrees C),
nonoxygenated cardioplegic solution containing potassium in a concentration
of either 25 or 40 mmol/L. Before infusion of the 25 mmol/L potassium
cardioplegic solution, both 5-hydroxytryptamine (1 x 10(-7) mol/L) and
papaverine (5 x 10(-6) mol/L) caused similar increases in flow (+21.2% +/-
1.6% and +22.8% +/- 1.6%, respectively). After cardioplegia, the
vasodilatory response to 5-hydroxytryptamine was completely lost and a
slight vasoconstriction was observed (-0.2% +/- 1.2%). However, there was
no significant change in the response to papaverine, which maintained a
+23.7% +/- 1.4% vasodilation. With the cardioplegic solution containing a
40 mmol/L concentration of potassium, the initial responses to
5-hydroxytryptamine and papaverine were again similar (+21.5% +/- 2.5% and
+24.1% +/- 3.0%, respectively). After cardioplegia, 5-hydroxytryptamine
caused a significant vasoconstriction (-4.3% +/- 1.1%), whereas the
response to papaverine was again maintained (+19.1% +/- 2.3%). The results
of this study support the concept that hyperkalemic crystalloid
cardioplegic solutions cause vascular damage possibly involving the
endothelium or its function, which may adversely affect vascular
responsiveness.
ARTICLES
Coronary vascular responsiveness to 5-hydroxytryptamine before and after infusion of hyperkalemic crystalloid cardioplegic solution in the rat heart. Possible evidence of endothelial damage
Cardiovascular Research, Rayne Institute, St. Thomas' Hospital, London, England.
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