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The Journal of Thoracic and Cardiovascular Surgery, Vol 98, 968-970, Copyright © 1989 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
CW Lillehei, PP O'Rourke, JP Vacanti and RK Crone
Between 1984 and 1988, 89 infants and children with severe respiratory
failure were supported by extracorporeal membrane oxygenation. Major
clinical diagnoses included congenital diaphragmatic hernias (34), meconium
aspiration syndrome (26), and sepsis (8). Extracorporeal membrane
oxygenation was used for patients with a predicted mortality rate of at
least 80% based on an oxygenation index greater than 0.4. Venoarterial
bypass was accomplished by way of right cervical cannulation of the common
carotid artery and internal jugular vein. Overall survival was 71% but
varied widely by diagnosis and progressively improved over time. The
average extracorporeal membrane oxygenation run was 5.7 days. Intracranial
hemorrhage was the most serious complication occurring in 16% of patients.
Mechanical circuit complications were seen in 22% but rarely related to
significant morbidity. Extracorporeal membrane oxygenation appears to
provide effective cardiopulmonary support for selected pediatric
respiratory problems. It affords those with potentially reversible
pathophysiology the temporal opportunity for successful medical or surgical
therapies.
ARTICLES
Role of extracorporeal membrane oxygenation in selected pediatric respiratory problems
Department of Surgery, Children's Hospital, Boston, MA 02115.
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P J DAVIS and L S SHEKERDEMIAN Meconium aspiration syndrome and extracorporeal membrane oxygenation Arch. Dis. Child. Fetal Neonatal Ed., January 1, 2001; 84(1): 1F - 3. [Full Text] |
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