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The Journal of Thoracic and Cardiovascular Surgery, Vol 98, 972-977, Copyright © 1989 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
D Novitzky, DK Cooper, CI Barton, A Greer, J Chaffin, J Grim and N Zuhdi
Two small, randomized, blind clinical trials comparing the administration
of triiodothyronine with that of placebo have been carried out in patients
undergoing myocardial revascularization. In patients with a left
ventricular ejection fraction of less than 30% (study I), triiodothyronine
administration at the end of operation and during the initial 24 hours
after operation was associated with a significantly reduced need for
conventional inotropic agents (p less than 0.02) and diuretics (p less than
0.02). In patients with a left ventricular ejection fraction of greater
than 40% (study II), triiodothyronine administration resulted in
significantly improved stroke volume (p less than 0.01) and cardiac output
(p less than 0.02) and reduced systemic (p less than 0.01) and pulmonary (p
less than 0.05) vascular resistances. There were no adverse reactions to
triiodothyronine in the dosages that were used. Triiodothyronine appears to
be beneficial to all patients undergoing open heart surgery.
ARTICLES
Triiodothyronine as an inotropic agent after open heart surgery
Oklahoma Transplantation Institute, Baptist Medical Center, Oklahoma City, OK 73112.
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