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J Thorac Cardiovasc Surg 2004;127:625-626
© 2004 The American Association for Thoracic Surgery

Editorial

Calcium antagonists and good results: association or causation?

Donald D. Glower, MDa,*

a Duke University Medical Center, Durham, NC USA

Received for publication October 30, 2003; accepted for publication November 3, 2003.

* Address for reprints: Donald D. Glower, MD, Duke University Medical Center, Box 3851, Durham, NC 27710, USA
glowe001@mc.duke.edu

The first 20% of the full text of this article appears below.


See related articles on pages 622 and 755.

 

Wijeysundera and colleagues1 retrospectively examined the effects of preoperative calcium antagonists on operative mortality and postoperative morbidity after cardiac surgery. Results, including propensity score analysis, showed significant reduction in operative mortality associated with use of calcium antagonists. Wijeysundera and colleagues1 concluded that a large randomized trial of perioperative calcium antagonists is indicated to test the hypothesis that calcium antagonists decrease perioperative morbidity and mortality.

This study is important because it is the largest study to examine the effects of calcium antagonists on perioperative mortality after cardiac surgery. The results are also important in that the risks versus benefits of calcium antagonists in cardiac patients remain controversial. The reduction in mortality was relatively large (roughly 50%), again implying that these results could save many . . . [Full Text of this Article]


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