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J Thorac Cardiovasc Surg 2006;132:10-11
© 2006 The American Association for Thoracic Surgery

Editorial

Brain death leads to abnormal contractile properties of the human donor right ventricle

Alden H. Harken, MD *

Department of Surgery, University of California, San Francisco, East Bay Department, San Francisco, Calif

Received for publication January 9, 2006; accepted for publication January 13, 2006.

* Address for reprints: Alden H. Harken, University of California, San Francisco, East Bay, Department of Surgery, 1411 East 31st Street, Oakland, CA 94602.

The first 20% of the full text of this article appears below.

GoIn a characteristically bold, yet bald, attempt to preserve priority in investigative inquiry, The Journal of Thoracic and Cardiovascular Surgery has, in this issue, disinterred an observation first introduced four centuries ago by Macbeth: "The time has been, that when the brains were out, the man would die, and there an end; but now they rise again ... ." 1 Go The transplantation community is now capable of scooping out your standard donor like a canoe. Thirty different tissue varieties can be successfully restored into welcoming recipients for years of effective functioning. Dying itself is, however, complex. We have evolved to avoid death. Dying provokes a constellation of signals that influence organ function in a receptor-dependent fashion. Receptor expression is gene controlled, and genome-wide scanning has confirmed high heritability correlating with the Framingham Heart Study. 2 Go As that great American philosopher Mae West once observed, "Too much of a good thing is wonderful." The editor of the Journal, himself no foreigner to stress, . . . [Full Text of this Article]


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Brain death leads to abnormal contractile properties of the human donor right ventricle
Serban C. Stoica, Duwarakan K. Satchithananda, Paul A. White, Linda Sharples, Jayan Parameshwar, Andrew N. Redington, and Stephen R. Large
J. Thorac. Cardiovasc. Surg. 2006 132: 116-123. [Abstract] [Full Text] [PDF]





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