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J Thorac Cardiovasc Surg 2008;135:18
© 2008 The American Association for Thoracic Surgery

Surgery for Acquired Cardiovascular Disease

Discussion

The first 20% of the full text of this article appears below.

John S. Ikonomidis (Charleston, SC). I congratulate Dr Della Corte for an outstanding study, which showed temporospatial changes in extracellular proteins, vascular smooth muscle density, and indexes of apoptosis in normal or aneurysmal ascending aortic specimens taken from patients with normal or stenotic BAVs or TAVs.

In particular, and in keeping with previous studies from this group, extracellular matrix protein changes were particularly important in the convexity of aneurysmal ascending aorta associated with BAVs. In addition, evidence of early SMC apoptosis was demonstrated. Of particular relevance here is evidence presented that anoikis, or apoptosis, which is induced by the loss of integrin-mediated cellular attachments, participates in the process of SMC attrition as the aneurysm develops. This, of course, makes sense because extracellular matrix remodeling and . . . [Full Text of this Article]


Related Article

Spatiotemporal patterns of smooth muscle cell changes in ascending aortic dilatation with bicuspid and tricuspid aortic valve stenosis: Focus on cell–matrix signaling
Alessandro Della Corte, Cesare Quarto, Ciro Bancone, Clotilde Castaldo, Franca Di Meglio, Daria Nurzynska, Luca S. De Santo, Marisa De Feo, Michelangelo Scardone, Stefania Montagnani, and Maurizio Cotrufo
J. Thorac. Cardiovasc. Surg. 2008 135: 8-18. [Abstract] [Full Text] [PDF]





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