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J Thorac Cardiovasc Surg 2008;135:260
© 2008 The American Association for Thoracic Surgery

Invited Commentary

Discussion

The first 20% of the full text of this article appears below.

Dr Nasser K. Altorki (New York, NY). Dr Litle, I congratulate you on a nice piece of work and nice presentation; I also congratulate your group on bringing this new field of microRNA expression profiles into the field of esophageal and other thoracic malignancies, particularly as related to using them as diagnostic tools, prognostic tools, and, most importantly I think, as tools for target discovery and mechanistically understanding better the biology. I think you have shown very nicely here that microRNA expression profiles can really distinguish histologies, AC versus SCC, and I think that you have also shown that the expression profiles can distinguish tumor from NSE.

From a mechanistic point of view, I do not know if you have had the opportunity to ascertain what the . . . [Full Text of this Article]






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