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J Thorac Cardiovasc Surg 2008;135:705-706
© 2008 The American Association for Thoracic Surgery

Brief Communication

Incidence of venous thromboembolism in patients undergoing thoracotomy for lung cancer

Francesco Dentali, MDa,*, Alessandra Malato, MDb, Walter Ageno, MDa, Andrea Imperatori, MDc, Massimo Cajozzo, MDd, Nicola Rotolo, MDc, James Douketis, MDe, Sergio Siragusa, MDb, Mark Crowther, MDe

a Department of Clinical Medicine, Insubria University, Varese, Italy
b Thrombosis/Haemostasis and Haematology Unit, University Hospital of Palermo, Palermo, Italy
c Center for Thoracic Surgery, University of Insubria, Varese, Italy
d Department of Surgery, Division of General and Thoracic Surgery, University of Palermo, Palermo, Italy
e Department of Medicine, McMaster University, Hamilton, Ontario, Canada

Received for publication August 23, 2007; accepted for publication October 2, 2007.

* Address for reprints: Francesco Dentali, MD, U.O. Medicina I, Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy. (Email: fdentali@libero.it).

The first 20% of the full text of this article appears below.

Limited information exists on the incidence of symptomatic venous thromboembolism (VTE) in patients undergoing chest surgery for lung cancer. Several factors increase the thromboembolic risk in patients undergoing surgery for lung cancer: the intrinsic procoagulant effect of cancer, extensive surgical intervention, dependent limb position in the operating room, and vessel injury consequent to the operation. Furthermore, these patients might be especially vulnerable to pulmonary embolism (PE) because of the loss of lung tissue and the presence of chronic obstructive pulmonary disease and cardiovascular diseases caused by smoking.1Go

Older studies found a very high incidence of thromboembolic events in these patients.2,3Go

However, the risk of thromboembolic complications in lung cancer surgery might have changed over the last years. Extensive use of antithrombotic prophylaxis, improvement in surgical techniques and perioperative care, and more prompt mobilization might have reduced the risk of VTE.

Therefore, the aim of our study was to provide up-to-date reliable . . . [Full Text of this Article]






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