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Luca Dainese
Fabio Barili
Paolo Biglioli
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J Thorac Cardiovasc Surg 2008;135:1189-1190
© 2008 The American Association for Thoracic Surgery

Letter to the Editor

Tissue-engineered heart valves: Bioreactor—yes or no?

Luca Dainese, MD, Fabio Barili, MD, Paolo Biglioli, MD

Department of Cardiac Surgery, University of Milan, Centro Cardiologico Monzino IRCCS, Milan, Italy

The first 20% of the full text of this article appears below.

To the Editor:

I read with great interest the article by Vincentelli and associates.1Go In this article the authors present the results of the effects of in situ injection of autologous bone marrow–derived mononuclear cells and mesenchymal stem cells (MSCs) on the outcome of xenogenic decellularized scaffolds in a lamb model. The main focus of this article is on a new method to reseed the cells in valve scaffolds consisting of an in situ injection of bone marrow cells into a porcine decellularized scaffold before implantation. Tissue-engineered heart valves created from MSCs and injected directly in a decellularized xenograft scaffold exhibited satisfactory hemodynamic aspects after 4 months.

Even . . . [Full Text of this Article]






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